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Details on Person Transcription of the heavy (H)-strand of mitochondrial DNA (...
| Class:Id | Summation:163261 |
|---|---|
| _displayName | Transcription of the heavy (H)-strand of mitochondrial DNA (... |
| _timestamp | 2026-04-22 21:48:28 |
| created | [InstanceEdit:163227] Gustafsson, C, 2005-04-25 22:00:00 |
| literatureReference | [LiteratureReference:163241] Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA [LiteratureReference:163245] The pattern of transcription of the human mitochondrial rRNA genes reveals two overlapping transcription units [LiteratureReference:163253] Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable [LiteratureReference:163258] Regulation of mitochondrial gene expression in mammalian cells [LiteratureReference:163255] Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination [LiteratureReference:164553] The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions |
| modified | [InstanceEdit:164557] Matthews, L, 2005-05-26 16:32:39 [InstanceEdit:9987659] May, Bruce, 2026-04-22 |
| text | Transcription of the heavy (H)-strand of mitochondrial DNA (mtDNA) involves two overlapping transcription units (Montoyaet al.,1982; Montoya et al., 1983). The first unit starts right upstream of the tRNAPhe gene and spans the tRNAPhe, rRNA 12S, rRNA 16S and tRNAVal genes (initiation site IH1). The other starts about 100 bp further downstream (initiation site IH2), at the boundary between tRNAPhe and rRNA12S genes, and produces a single polycistronic RNA that encompasses almost the entire length of the H-strand. The ribosomal transcription unit is transcribed at a much higher rate compared to the other transcription unit and control of its expression is exerted both at the level of initiation and termination (Gelfand and Attardi, 1981; Attardi et al., 1990). A central role in the control of termination has been attributed to the mitochondrial transcription termination factor (MTERF1, also called mTERF), a 39-kDa protein that binds to a 28-base pair region of mtDNA located within the tRNALeu(UUR) gene, at a position immediately downstream of the rRNA 16S gene (Fernandez-Silva et al.,1997; Kruse et al., 1989). |
| (summation) | [Pathway:163316] Mitochondrial transcription termination [Homo sapiens] |
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No pathways have been reviewed or authored by Transcription of the heavy (H)-strand of mitochondrial DNA (... (163261)
