Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

Class:Id	Reaction:163217
_displayName	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
_doRelease	TRUE
_timestamp	2024-05-16 14:51:57
authored	[InstanceEdit:163947] Jassal, Bijay, 2005-05-10
catalystActivity	[CatalystActivity:164321] NADH dehydrogenase (ubiquinone) activity of Complex I [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:163212] Jassal, Bijay, 2005-04-25
crossReference	[DatabaseIdentifier:9864485] RHEA:29092
figure	[Figure:163369] /figures/complex_I.jpg
goBiologicalProcess	[GO_BiologicalProcess:15809] mitochondrial electron transport, NADH to ubiquinone
input	[SimpleEntity:29362] NADH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:73663] CoQ [mitochondrial inner membrane]
internalReviewed	[InstanceEdit:9909139] D'Eustachio, Peter, 2024-04-29
literatureReference	[LiteratureReference:164765] cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: [LiteratureReference:164787] The nuclear encoded subunits of complex I from bovine heart mitochondria [LiteratureReference:164782] Structural organization of mitochondrial human complex I: role of the ND4 [LiteratureReference:164775] The gross structure of the respiratory complex I: a Lego System [LiteratureReference:164786] Human NADH:ubiquinone oxidoreductase [LiteratureReference:164774] The energy-transducing NADH: quinone oxidoreductase, complex I [LiteratureReference:8933117] The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration [LiteratureReference:8933116] A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae
modified	[InstanceEdit:163370] Jassal, Bijay, 2005-04-28 [InstanceEdit:163947] Jassal, Bijay, 2005-05-10 [InstanceEdit:163952] Jassal, Bijay, 2005-05-10 [InstanceEdit:164323] Jassal, Bijay, 2005-05-17 [InstanceEdit:164534] Jassal, Bijay, 2005-05-26 [InstanceEdit:164783] Jassal, Bijay, 2005-06-21 [InstanceEdit:164874] Jassal, Bijay, 2005-07-04 [InstanceEdit:164935] Jassal, Bijay, 2005-07-22 [InstanceEdit:169272] Jassal, Bijay, 2005-11-25 [InstanceEdit:170174] Gopinathrao, G, 2005-12-25 02:17:30 [InstanceEdit:451020] D'Eustachio, P, 2009-12-24 [InstanceEdit:1433060] Jassal, Bijay, 2011-07-08 [InstanceEdit:5689038] Jassal, Bijay, 2015-04-21 [InstanceEdit:5689705] Jassal, Bijay, 2015-04-24 [InstanceEdit:5689941] Jassal, Bijay, 2015-04-27 [InstanceEdit:8933113] Jassal, Bijay, 2016-08-03 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9864499] Stephan, Ralf, 2024-03-07 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9909138] Stephan, Ralf, 2024-04-29 [InstanceEdit:9910655] Stephan, Ralf, 2024-05-16 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16
name	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 NADH enters the respiratory chain at Complex I
output	[SimpleEntity:113526] NAD+ [mitochondrial matrix] [SimpleEntity:163953] H+ [mitochondrial intermembrane space] [SimpleEntity:163953] H+ [mitochondrial intermembrane space] [SimpleEntity:163953] H+ [mitochondrial intermembrane space] [SimpleEntity:163953] H+ [mitochondrial intermembrane space] [SimpleEntity:2162198] CoQH2 [mitochondrial inner membrane]
precedingEvent	[Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70982] FH tetramer hydrates fumarate to L-malate [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:70971] ACO2 isomerizes citrate [Homo sapiens] [Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [BlackBoxEvent:109342] Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation [Homo sapiens] [Reaction:109338] Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA [Homo sapiens] [BlackBoxEvent:109339] Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation [Homo sapiens] [Reaction:77254] (S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H [Homo sapiens] [Reaction:77256] 2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA [Homo sapiens] [Reaction:77303] (S)-3-Hydroxyhexadecanoyl-CoA+NAD => 3-Oxopalmitoyl-CoA+NADH+H [Homo sapiens] [Reaction:77301] trans-Hexadec-2-enoyl-CoA+H2O => (S)-3-Hydroxyhexadecanoyl-CoA [Homo sapiens] [Reaction:77283] (S)-3-Hydroxytetradecanoyl-CoA+NAD => 3-Oxotetradecanoyl-CoA+NADH+H [Homo sapiens] [Reaction:77277] trans-Tetradec-2-enoyl-CoA+H2O => (S)-3-Hydroxytetradecanoyl-CoA [Homo sapiens] [Reaction:77312] (S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H [Homo sapiens] [Reaction:77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA [Homo sapiens] [Reaction:77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Homo sapiens] [Reaction:77325] trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA [Homo sapiens] [Reaction:77331] (S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H [Homo sapiens] [Reaction:77333] trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA [Homo sapiens] [Reaction:77342] (S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H [Homo sapiens] [Reaction:77344] trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA [Homo sapiens] [Reaction:164651] Electron transfer from ubiquinol to cytochrome c of complex III [Homo sapiens] [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Homo sapiens] [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex [Homo sapiens] [Reaction:169270] ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 [Homo sapiens] [Reaction:163214] Electron transfer from reduced cytochrome c to molecular oxygen [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:8933104] Positive regulation by 'COQ10A,B [mitochondrial inner membrane]'
releaseDate	2006-01-23
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359300] R-HSA-163217.6
structureModified	[InstanceEdit:9909138] Stephan, Ralf, 2024-04-29
summation	[Summation:163948] Complex I (NADH:ubiquinone oxidoreductase or NADH dehydrogen...
(hasEvent)	[Pathway:611105] Respiratory electron transport [Homo sapiens]
(precedingEvent)	[Reaction:163209] Electron transfer from ubiquinone to ubiquinol [Homo sapiens] [Reaction:164651] Electron transfer from ubiquinol to cytochrome c of complex III [Homo sapiens] [Reaction:164834] Enzyme-bound ATP is released [Homo sapiens] [Reaction:166219] FA anion picks up a proton [Homo sapiens] [Reaction:170026] UCP1 imports a proton [Homo sapiens] [Reaction:9864415] AAC1 imports a proton [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782885] Update Tracker - [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - v58:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9784064] Update Tracker - [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - v54:[modifyText] [_UpdateTracker:9784803] Update Tracker - [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - v53:[modifyText] [_UpdateTracker:9910999] Update Tracker - [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - v89:[add_removeOutput]
[Change default viewing format]

No pathways have been reviewed or authored by Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (163217)