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Details on Person Transfer of electrons through the succinate dehydrogenase complex

Class:Id	Reaction:163213
_displayName	Transfer of electrons through the succinate dehydrogenase complex
_doRelease	TRUE
_timestamp	2024-05-16 14:58:11
authored	[InstanceEdit:164648] Jassal, Bijay, 2005-06-10
catalystActivity	[CatalystActivity:70993] succinate dehydrogenase (quinone) activity of SDH complex [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:163212] Jassal, Bijay, 2005-04-25
crossReference	[DatabaseIdentifier:9854209] RHEA:13714
goBiologicalProcess	[GO_BiologicalProcess:15811] mitochondrial electron transport, succinate to ubiquinone
inferredFrom	[Reaction:165642] Transfer of electrons through the bovine succinate dehydrogenase complex [Bos taurus]
input	[SimpleEntity:73663] CoQ [mitochondrial inner membrane] [SimpleEntity:113536] SUCCA [mitochondrial matrix]
internalReviewed	[InstanceEdit:9908261] D'Eustachio, Peter, 2024-04-20 [InstanceEdit:9909139] D'Eustachio, Peter, 2024-04-29
literatureReference	[LiteratureReference:8874523] The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase [LiteratureReference:8874501] Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis [LiteratureReference:8874515] Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells
modified	[InstanceEdit:163949] Jassal, Bijay, 2005-05-10 [InstanceEdit:163950] Jassal, Bijay, 2005-05-10 [InstanceEdit:163951] Jassal, Bijay, 2005-05-10 [InstanceEdit:163956] Jassal, Bijay, 2005-05-10 [InstanceEdit:163957] Jassal, Bijay, 2005-05-10 [InstanceEdit:164534] Jassal, Bijay, 2005-05-26 [InstanceEdit:164648] Jassal, Bijay, 2005-06-10 [InstanceEdit:164874] Jassal, Bijay, 2005-07-04 [InstanceEdit:164935] Jassal, Bijay, 2005-07-22 [InstanceEdit:165651] Jassal, Bijay, 2005-08-09 [InstanceEdit:169272] Jassal, Bijay, 2005-11-25 [InstanceEdit:170174] Gopinathrao, G, 2005-12-25 02:17:30 [InstanceEdit:450991] D'Eustachio, P, 2009-12-24 [InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06 [InstanceEdit:8874509] Jassal, Bijay, 2016-05-24 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853494] Stephan, Ralf, 2023-11-16 [InstanceEdit:9854201] Stephan, Ralf, 2023-11-23 [InstanceEdit:9864499] Stephan, Ralf, 2024-03-07 [InstanceEdit:9908260] Stephan, Ralf, 2024-04-20 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 [InstanceEdit:9909138] Stephan, Ralf, 2024-04-29 [InstanceEdit:9910689] Stephan, Ralf, 2024-05-16
name	Transfer of electrons through the succinate dehydrogenase complex Succinate + Q10 => Fumarate + Q10H2
output	[SimpleEntity:113588] FUMA [mitochondrial matrix] [SimpleEntity:2162198] CoQH2 [mitochondrial inner membrane]
precedingEvent	[Reaction:70997] SUCLG1/A2 cleaves succinyl-CoA [Homo sapiens] [Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA [Homo sapiens] [Reaction:71775] SUCLG1/G2 cleaves succinyl-CoA [Homo sapiens] [Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:71010] MUT isomerises L-MM-CoA to SUCC-CoA [Homo sapiens] [Reaction:888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Homo sapiens] [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA [Homo sapiens] [Reaction:9855252] SDHA:SDHB binds to SDHC:SDHD [Homo sapiens] [Reaction:9855212] SDHA binds to SDHB [Homo sapiens] [Reaction:164651] Electron transfer from ubiquinol to cytochrome c of complex III [Homo sapiens] [Reaction:163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 [Homo sapiens] [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex [Homo sapiens] [Reaction:169270] ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 [Homo sapiens] [Reaction:163214] Electron transfer from reduced cytochrome c to molecular oxygen [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:8874496] Negative regulation by 'TRAP1 [mitochondrial matrix]' [NegativeRegulation:9854200] Negative regulation by 'itaconate [mitochondrial matrix]'
releaseDate	2005-04-11
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358648] R-HSA-163213.7
structureModified	[InstanceEdit:9864499] Stephan, Ralf, 2024-03-07 [InstanceEdit:9909138] Stephan, Ralf, 2024-04-29
summation	[Summation:164649] This event is deduced on the basis of bovine experimental da...
(hasEvent)	[Pathway:611105] Respiratory electron transport [Homo sapiens]
(precedingEvent)	[Reaction:163209] Electron transfer from ubiquinone to ubiquinol [Homo sapiens] [Reaction:164651] Electron transfer from ubiquinol to cytochrome c of complex III [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782831] Update Tracker - [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex - v58:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9784305] Update Tracker - [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex - v54:[modifyText] [_UpdateTracker:9864204] Update Tracker - [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex - v88:[add_removeCatalystActivity, add_removeInput, add_removeOutput] [_UpdateTracker:9910937] Update Tracker - [Reaction:163213] Transfer of electrons through the succinate dehydrogenase complex - v89:[addRegulator, add_removeOutput]
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