Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Recruitment of Telomerase RNP to the Telomeric Chromosome End

Class:IdReaction:163096
_displayNameRecruitment of Telomerase RNP to the Telomeric Chromosome End
_doReleaseTRUE
_timestamp2022-02-22 18:21:00
authored[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:163097] Gillespie, ME, 2005-04-18 03:27:10
edited[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
figure[Figure:163094] /figures/telomerase_recruit.jpg
goBiologicalProcess[GO_BiologicalProcess:18229] telomere maintenance via telomerase
input[Complex:163101] Telomerase RNP [nucleoplasm] [Homo sapiens]
[Complex:9671076] Telomeric G-strand chromosome end:Shelterin [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:5686112] RTEL1 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:177183] Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1
[LiteratureReference:9671082] TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
[LiteratureReference:9671079] The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
[LiteratureReference:9671080] Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
[LiteratureReference:9671089] Identification of human TERT elements necessary for telomerase recruitment to telomeres
[LiteratureReference:9671167] RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
[LiteratureReference:9671181] TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding
[LiteratureReference:9686519] CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
modified[InstanceEdit:164621] Gillespie, ME, 2005-06-03 18:18:35
[InstanceEdit:164688] Gillespie, ME, 2005-06-14 19:41:03
[InstanceEdit:164694] Gillespie, ME, 2005-06-15 16:56:59
[InstanceEdit:174909] Gillespie, ME, 2006-02-22 18:57:49
[InstanceEdit:176727] Gillespie, ME, 2006-03-09 19:06:16
[InstanceEdit:176736] Gillespie, ME, 2006-03-09 19:42:21
[InstanceEdit:177234] Gillespie, ME, 2006-03-24 04:34:59
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177977] Gillespie, ME, 2006-04-13 15:15:41
[InstanceEdit:180773] Gillespie, ME, 2006-06-05 03:13:58
[InstanceEdit:180785] Gillespie, ME, 2006-06-05 04:16:53
[InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19
[InstanceEdit:182750] Gillespie, ME, 2006-07-12 20:44:26
[InstanceEdit:182764] Gillespie, ME, 2006-07-13 01:18:53
[InstanceEdit:182787] Gillespie, ME, 2006-07-13 18:34:39
[InstanceEdit:183139] Gillespie, ME, 2006-07-21 18:01:36
[InstanceEdit:183148] Gopinathrao, G, 2006-07-24 03:46:25
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9671096] Orlic-Milacic, Marija, 2019-12-18
[InstanceEdit:9671187] Orlic-Milacic, Marija, 2019-12-18
[InstanceEdit:9676295] Orlic-Milacic, Marija, 2020-02-11
[InstanceEdit:9686483] Orlic-Milacic, Marija, 2020-05-04
[InstanceEdit:9686586] Orlic-Milacic, Marija, 2020-05-04
[InstanceEdit:9686669] Orlic-Milacic, Marija, 2020-05-04
[InstanceEdit:9766494] Orlic-Milacic, Marija, 2022-02-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRecruitment of Telomerase RNP to the Telomeric Chromosome End
negativePrecedingEvent[NegativePrecedingEvent:9766485] Futile Cycle: Disassociation of Telomerase RNP and the Chromosome End
output[Complex:163088] Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:9686585] Negative regulation by 'CCNA:p-T160-CDK2 [nucleoplasm]'
[PositiveRegulation:9686584] Positive regulation by 'PP6-PPP6R3 [nucleoplasm]'
releaseDate2006-08-02
reviewed[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38
[InstanceEdit:9672970] Gillespie, Marc E, 2020-01-03
[InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9671059] Orlic-Milacic, Marija, 2019-12-18
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358290] R-HSA-163096.6
summation[Summation:174908] Studies in yeast and human cells indicate that recruitment o...
(hasEvent)[Pathway:171319] Telomere Extension By Telomerase [Homo sapiens]
(inferredFrom)[Reaction:417077] Recruitment of telomerase RNP to a telomeric chromosome end [Gallus gallus]
(precedingEvent)[Reaction:163099] Alignment Of The RNA Template On The Telomeric Chromosome End [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776939] Update Tracker - [Reaction:163096] Recruitment of Telomerase RNP to the Telomeric Chromosome End - v73:[addLiteratureReference, addRegulator, modifyText]
[_UpdateTracker:9777289] Update Tracker - [Reaction:163096] Recruitment of Telomerase RNP to the Telomeric Chromosome End - v72:[addLiteratureReference, add_removeInput, modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by Recruitment of Telomerase RNP to the Telomeric Chromosome End (163096)
Follow Reactome