Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate

Class:IdReaction:1630304
_displayNameGALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate
_doReleaseTRUE
_timestamp2025-03-14 09:02:55
authored[InstanceEdit:1630307] Jassal, B, 2011-10-05
catalystActivity[CatalystActivity:1630318] N-acetylgalactosamine-6-sulfatase activity of GALNS dimer [lysosomal lumen]
compartment[Compartment:161320] lysosomal lumen
created[InstanceEdit:1630307] Jassal, B, 2011-10-05
edited[InstanceEdit:1630307] Jassal, B, 2011-10-05
input[SimpleEntity:1605715] H2O [lysosomal lumen]
[SimpleEntity:2105007] Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal [lysosomal lumen]
isChimericFALSE
literatureReference[LiteratureReference:1630308] Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase
[LiteratureReference:1630323] N-acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics
[LiteratureReference:1606825] Crystal structure of a covalent intermediate of endogenous human arylsulfatase A
[LiteratureReference:1606802] Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis
[LiteratureReference:1630314] Mucopolysaccharidosis type IVA. N-acetylgalactosamine-6-sulfate sulfatase exonic point mutations in classical Morquio and mild cases
[LiteratureReference:9941150] The structure of human GALNS reveals the molecular basis for mucopolysaccharidosis IV A
modified[InstanceEdit:1638090] Jassal, B, 2011-10-07
[InstanceEdit:1678776] Jassal, B, 2011-10-19
[InstanceEdit:1793216] Jassal, B, 2011-10-21
[InstanceEdit:2022912] Jassal, B, 2011-12-01
[InstanceEdit:2105013] Jassal, B, 2012-02-09
[InstanceEdit:2162219] Jassal, B, 2012-03-16
[InstanceEdit:2245320] Jassal, B, 2012-05-11
[InstanceEdit:2247519] Jassal, B, 2012-05-14
[InstanceEdit:2428935] Jassal, B, 2012-08-09
[InstanceEdit:2457639] Jassal, B, 2012-08-27
[InstanceEdit:9036091] Jassal, Bijay, 2018-01-30
[InstanceEdit:9036259] Jassal, Bijay, 2018-01-31
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
[InstanceEdit:9942322] Stephan, Ralf, 2025-03-14
nameGALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate
output[SimpleEntity:1606845] SO4(2-) [lysosomal lumen]
[SimpleEntity:2104997] Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal [lysosomal lumen]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294994] R-HSA-1630304.4
summation[Summation:1630305] N-acetylgalactosamine 6-sulfate sulfatase (GALNS) hydrolyses...
(hasEvent)[Pathway:2022857] Keratan sulfate degradation [Homo sapiens]
(normalReaction)[FailedReaction:2263490] Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate [Homo sapiens]
(precedingEvent)[Reaction:1630306] GLB1 hydrolyses a glycosaminoglycan [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788371] Update Tracker - [Reaction:1630304] GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate - v42:[modifyText]
[_UpdateTracker:9953663] Update Tracker - [Reaction:1630304] GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate - v93:[modifyText, removeLiteratureReference]
[Change default viewing format]
No pathways have been reviewed or authored by GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (1630304)
Follow Reactome