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Details on Person During the early stages of mitosis, Cdc2 and PLK1 cooperate ...
| Class:Id | Summation:163025 |
|---|---|
| _displayName | During the early stages of mitosis, Cdc2 and PLK1 cooperate ... |
| _timestamp | 2011-10-07 14:30:56 |
| created | [InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23 |
| literatureReference | [LiteratureReference:163011] Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1 |
| modified | [InstanceEdit:1638117] Orlic-Milacic, M, 2011-10-07 |
| text | During the early stages of mitosis, Cdc2 and PLK1 cooperate to phosphorylate Emi1 and this modification induces Emi1 degradation through a Skp1-Cullin1 F-box protein (SCF) ubiquitin ligase-mediated proteolysis. Degradation of Emi1 permits activation of anaphase promoting complex and thereby the onset of anaphase. |
| (summation) | [Reaction:163010] Down Regulation of Emi1 through Phosphorylation of Emi1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by During the early stages of mitosis, Cdc2 and PLK1 cooperate ... (163025)
