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Details on Person Down Regulation of Emi1 through Phosphorylation of Emi1

Class:Id	Reaction:163010
_displayName	Down Regulation of Emi1 through Phosphorylation of Emi1
_doRelease	TRUE
_timestamp	2023-03-17 21:39:14
authored	[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
catalystActivity	[CatalystActivity:156714] protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:163007] Gillespie, ME, 2005-04-12 04:40:16
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure	[Figure:163023] /figures/polokinases_Emi1.jpg
input	[EntityWithAccessionedSequence:174060] FBXO5 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:163033] Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
modified	[InstanceEdit:163970] Gillespie, ME, 2005-05-10 18:50:56 [InstanceEdit:164590] Gillespie, ME, 2005-06-01 14:43:03 [InstanceEdit:353067] Gillespie, ME, 2008-06-10 19:48:57 [InstanceEdit:3159224] Orlic-Milacic, M, 2013-02-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9612922] Orlic-Milacic, Marija, 2018-07-03 [InstanceEdit:9615420] Orlic-Milacic, Marija, 2018-08-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9831004] D'Eustachio, Peter, 2023-03-17
name	Down Regulation of Emi1 through Phosphorylation of Emi1
output	[EntityWithAccessionedSequence:163049] p-FBXO5 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:3002798] Cytosolic PLK1 translocates to the nucleus [Homo sapiens] [Reaction:3000327] PLK1 phosphorylates BORA [Homo sapiens]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359229] R-HSA-163010.4
summation	[Summation:163025] During the early stages of mitosis, Cdc2 and PLK1 cooperate ...
(hasEvent)	[Pathway:68881] Mitotic Metaphase/Anaphase Transition [Homo sapiens] [Pathway:156677] Polo-like kinases [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779118] Update Tracker - [Reaction:163010] Down Regulation of Emi1 through Phosphorylation of Emi1 - v66:[addInput, addOutput] [_UpdateTracker:9788995] Update Tracker - [Reaction:163010] Down Regulation of Emi1 through Phosphorylation of Emi1 - v39:[modifyText] [_UpdateTracker:9791915] Update Tracker - [Reaction:163010] Down Regulation of Emi1 through Phosphorylation of Emi1 - v25:[add_removeInput]
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