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Details on Person PLK1-dependent phosphorylation of the cohesin subunit RAD21 ...

Class:IdSummation:163002
_displayNamePLK1-dependent phosphorylation of the cohesin subunit RAD21 ...
_timestamp2011-10-07 14:31:12
created[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
literatureReference[LiteratureReference:163985] Preferential cleavage of chromatin-bound cohesin after targeted phosphorylation by Polo-like kinase
[LiteratureReference:163024] Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast
modified[InstanceEdit:163994] Gillespie, ME, 2005-05-10 20:06:49
[InstanceEdit:1638121] Orlic-Milacic, M, 2011-10-07
textPLK1-dependent phosphorylation of the cohesin subunit RAD21 (SCC1) promotes cleavage of RAD21 prior to the onset of anaphase. Destruction of securin by APC/Cdc20-dependent proteolysis permits separase to cleave RAD21, resulting in sister-chromatid separation.
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