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Details on Person UniProt:Q9BQQ3 GORASP1
| Class:Id | ReferenceGeneProduct:162940 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-440 added on Fri February 6 2015;initiator methionine:1 for 162940 removed on Fri Nov 03 2023;initiator methionine: for 162940 added on Fri Nov 03 2023;initiator methionine: for 162940 removed on Fri Aug 15 2025;initiator methionine:1 for 162940 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BQQ3 GORASP1 |
| _timestamp | 2025-08-15 21:07:27 |
| chain | initiator methionine:1 chain:2-440 |
| checksum | 1187C0356E16CE00 |
| comment | FUNCTION Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936).SUBUNIT Homodimer. Forms higher-order oligomers under interphase but not mitotic conditions. Dimers of the protein on one membrane might be able to interact with dimers on another and so stack cisternae (PubMed:26363069). Interacts with the C-terminus of GOLGA2/GM130 under both mitotic and non-mitotic conditions (PubMed:16489344, PubMed:26363069). The interaction is critical for the correct targeting of both proteins to the cis-Golgi. Interacts with TMED2 and TMED3 (By similarity).INTERACTION Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.PTM Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis.PTM Myristoylated.SIMILARITY Belongs to the GORASP family. |
| created | [InstanceEdit:162939] Gillespie, ME, 2005-04-12 02:09:17 |
| description | recommendedName: Golgi reassembly-stacking protein 1 alternativeName: Golgi peripheral membrane protein p65 alternativeName: Golgi phosphoprotein 5 shortName: GOLPH5 alternativeName: Golgi reassembly-stacking protein of 65 kDa shortName evidence="12 15"GRASP65 |
| geneName | GORASP1 GOLPH5 GRASP65 |
| identifier | Q9BQQ3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Golgi apparatus Lipoprotein Membrane Metal-binding Myristate Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Transport Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GORASP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002369] ENSEMBL:ENSG00000114745 GORASP1 [Homo sapiens] |
| secondaryIdentifier | GORS1_HUMAN B3KWC8 Q3SYG7 Q8N272 Q96H42 |
| sequenceLength | 440 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:148163] UniProt:Q9BQQ3-2 GORASP1 [Homo sapiens] [ReferenceIsoform:148164] UniProt:Q9BQQ3-3 GORASP1 [Homo sapiens] [ReferenceIsoform:413343] UniProt:Q9BQQ3-1 GORASP1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:162937] p-GORASP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:162984] GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Homo sapiens] [EntityWithAccessionedSequence:2172182] p-T216,S274,S373-GORASP1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:2314415] p-S189,T216,S274,S373-GORASP1 [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:6808767] GORASP1 [Golgi membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:162938] phosphorylated residue at unknown position [ModifiedResidue:2172186] O-phospho-L-serine at 274 [ModifiedResidue:2311322] O-phospho-L-threonine at 216 [ModifiedResidue:2311323] O-phospho-L-serine at 373 [ModifiedResidue:2314417] O-phospho-L-serine at 189 |
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No pathways have been reviewed or authored by UniProt:Q9BQQ3 GORASP1 (162940)
