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Details on Person Glycosylphosphatidyl inositol (GPI) acts as a membrane ancho...
| Class:Id | Summation:162766 |
|---|---|
| _displayName | Glycosylphosphatidyl inositol (GPI) acts as a membrane ancho... |
| _timestamp | 2005-05-19 19:24:50 |
| created | [InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34 |
| literatureReference | [LiteratureReference:162776] Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis [LiteratureReference:162833] Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo [LiteratureReference:162773] GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol |
| modified | [InstanceEdit:163064] D'Eustachio, P, 2005-04-17 22:59:09 [InstanceEdit:164440] D'Eustachio, P, 2005-05-19 19:23:48 |
| text | Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of nine reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring. This pathway is shown in the figure. Two additional reactions, not shown, allow the synthesis of variant forms of GPI, one with an additional mannose residue and one with an additional ethanolamine (Tauron et al. 2004; Shishioh et al. 2005). These variant GPI molecules may be used for tissue-specific protein modifications, or may function independently. The steps of GPI synthesis were first identified by isolating large numbers of mutant cell lines that had lost the ability to express GPI anchored proteins on their surfaces. Somatic cell hybrid analyses of these lines allowed the definition of complementation groups corresponding to distinct mutated genes, and cDNAs corresponding to normal forms of these genes were identified on the basis of their abilities to restore normal cell surface protein expression in mutant cells. Co-precipitation experiments with tagged cloned proteins have allowed the identification of additional proteins involved in GPI anchor biosynthesis. |
| (summation) | [Pathway:162710] Synthesis of glycosylphosphatidylinositol (GPI) [Homo sapiens] |
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