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Details on Person In the fourth step of GPI synthesis, an acyl group (typicall...

Class:IdSummation:162701
_displayNameIn the fourth step of GPI synthesis, an acyl group (typicall...
_timestamp2006-01-13 18:54:14
created[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
literatureReference[LiteratureReference:162841] PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor
modified[InstanceEdit:170720] D'Eustachio, P, 2006-01-13 18:54:09
textIn the fourth step of GPI synthesis, an acyl group (typically palmitate) is transferred from acyl CoA to glucosaminyl-PI. Mutagenesis and cloning studies suggest that a single protein, PIG-W, catalyzes this reaction (Murakami et al. 2003).
(summation)[Reaction:162683] glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH [Homo sapiens]
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