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Details on Person In the seventh reaction of GPI synthesis, a second mannose r...

Class:Id	Summation:162685
_displayName	In the seventh reaction of GPI synthesis, a second mannose r...
_timestamp	2005-05-21 16:15:04
created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
literatureReference	[LiteratureReference:162837] Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly [LiteratureReference:162795] PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol
modified	[InstanceEdit:164486] D'Eustachio, P, 2005-05-21 16:13:58
text	In the seventh reaction of GPI synthesis, a second mannose residue is added to the glycolipid on the lumenal face of the endoplasmic reticulum membrane. PIG-V was identified as the catylyst, or a component of the catalyst, of this reaction, on the basis of its ability to correct the metabolic defects of yeast and mammalian mutant cells arrested at this stage of the GPI synthetic process (Fabre et al. 2005; Kang et al. 2005).
(summation)	[Reaction:162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate [Homo sapiens]
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