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Details on Person At mitotic entry, Plk1 phosphorylates and activates Cdc25C p...
| Class:Id | Summation:162662 |
|---|---|
| _displayName | At mitotic entry, Plk1 phosphorylates and activates Cdc25C p... |
| _timestamp | 2013-08-23 16:43:07 |
| created | [InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23 |
| modified | [InstanceEdit:1458446] D'Eustachio, P, 2011-07-21 [InstanceEdit:4088434] Orlic-Milacic, M, 2013-08-13 [InstanceEdit:4410470] Orlic-Milacic, M, 2013-08-23 |
| text | At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A (Watanabe et al. 2004). Plk1 also phosphorylates and inhibits Myt1 activity (Sagata 2005). Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1. PLK1 phosphorylates and activates the transcription factor FOXM1 which stimulates the expression of a number of genes needed for G2/M transition, including PLK1, thereby creating a positive feedback loop (Laoukili et al. 2005, Fu et al. 2008, Sadasivam et al. 2012, Chen et al. 2013). |
| (summation) | [Pathway:156711] Polo-like kinase mediated events [Homo sapiens] |
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