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Details on Person Activation of the Anaphase Promoting Complex (APC) by PLK1

Class:Id	Reaction:162659
_displayName	Activation of the Anaphase Promoting Complex (APC) by PLK1
_doRelease	FALSE
_timestamp	2016-07-15 23:49:58
authored	[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
catalystActivity	[CatalystActivity:164602] protein serine/threonine kinase activity of PLK1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:162660] Gillespie, ME, 2005-04-04 01:40:57
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure	[Figure:162989] /figures/polokinases_GRASP65.jpg
goBiologicalProcess	[GO_BiologicalProcess:6808149] positive regulation of ubiquitin protein ligase activity
input	[EntityWithAccessionedSequence:162984] GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:162969] Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [LiteratureReference:2314408] Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand
modified	[InstanceEdit:162998] Gillespie, ME, 2005-04-12 02:12:31 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:163968] Gillespie, ME, 2005-05-10 18:50:27 [InstanceEdit:164590] Gillespie, ME, 2005-06-01 14:43:03 [InstanceEdit:164604] Gillespie, ME, 2005-06-02 23:07:06 [InstanceEdit:164605] Gillespie, ME, 2005-06-03 00:35:11 [InstanceEdit:164606] Gillespie, ME, 2005-06-03 00:55:05 [InstanceEdit:1547414] D'Eustachio, P, 2011-08-27 [InstanceEdit:1638114] Orlic-Milacic, M, 2011-10-07 [InstanceEdit:2314412] Orlic-Milacic, M, 2012-06-06 [InstanceEdit:3168183] Gillespie, ME, 2013-02-23 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Activation of the Anaphase Promoting Complex (APC) by PLK1
output	[EntityWithAccessionedSequence:162937] p-GORASP1 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8908904] R-HSA-162659.1
summation	[Summation:162661] During the early stages of mitosis, mitotic kinases includin...
(updatedInstance)	[_UpdateTracker:9788943] Update Tracker - [Reaction:162659] Activation of the Anaphase Promoting Complex (APC) by PLK1 - v39:[modifyText] [_UpdateTracker:9789514] Update Tracker - [Reaction:162659] Activation of the Anaphase Promoting Complex (APC) by PLK1 - v38:[addInput, addOutput]
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