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Details on Person Inactivation of Myt1 kinase

Class:IdReaction:162657
_displayNameInactivation of Myt1 kinase
_doReleaseTRUE
_timestamp2022-02-08 21:50:38
authored[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
catalystActivity[CatalystActivity:156714] protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:156670] Gillespie, ME, 2004-12-09 02:18:13
edited[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure[Figure:162987] /figures/polokinases_Myt1.jpg
goBiologicalProcess[GO_BiologicalProcess:171508] regulation of cell cycle
input[EntityWithAccessionedSequence:74386] PKMYT1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
literatureReference[LiteratureReference:162982] Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate
modified[InstanceEdit:162996] Gillespie, ME, 2005-04-12 02:12:20
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20
[InstanceEdit:2671734] D'Eustachio, P, 2012-11-23
[InstanceEdit:8933147] Orlic-Milacic, Marija, 2016-08-03
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9615421] Orlic-Milacic, Marija, 2018-08-03
[InstanceEdit:9764039] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameInactivation of Myt1 kinase
negativePrecedingEvent[NegativePrecedingEvent:9764036] Futile Cycle: PLK1 phosphorylates FOXM1
output[EntityWithAccessionedSequence:162650] p-PKMYT1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent
releaseDate2005-04-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359542] R-HSA-162657.6
summation[Summation:162985] At mitotic entry Plk1 phosphorylates and inhibits Myt1 activ...
(hasEvent)[Pathway:156711] Polo-like kinase mediated events [Homo sapiens]
(precedingEvent)[Reaction:170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779178] Update Tracker - [Reaction:162657] Inactivation of Myt1 kinase - v66:[addInput, addOutput]
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