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Details on Person p-Y542,Y580-PTPN11 [cytosol]
Class:Id EntityWithAccessionedSequence:162573
_displayName p-Y542,Y580-PTPN11 [cytosol]
_timestamp 2023-10-31 22:14:43
compartment [Compartment:70101] cytosol
created [InstanceEdit:162564] Gopinathrao, G, 2005-03-31 12:46:21
endCoordinate 593
hasModifiedResidue [ModifiedResidue:162572] O4'-phospho-L-tyrosine at 542 [ModifiedResidue:190365] O4'-phospho-L-tyrosine at 580
modified [InstanceEdit:166815] Schmidt, EE, 2005-09-19 04:13:24 [InstanceEdit:190366] de Bono, B, 2007-01-02 13:21:44 [InstanceEdit:532641] Jupe, S, 2010-03-02 [InstanceEdit:1369100] Jupe, S, 2011-07-04 [InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:3322333] Wu, G, 2013-05-03 [InstanceEdit:3322334] Wu, G, 2013-05-03 [InstanceEdit:9822897] D'Eustachio, Peter, 2022-12-30 [InstanceEdit:9851827] D'Eustachio, Peter, 2023-10-31
name p-Y542,Y580-PTPN11 p(Y542,580)-SHP2 Tyrosine phosphorylated SHP2 PTPN11
referenceEntity [ReferenceGeneProduct:62439] UniProt:Q06124 PTPN11 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1107249] R-HSA-162573.3
startCoordinate 1
(activeUnit) [CatalystActivity:9674825] protein tyrosine phosphatase activity of CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane]
(hasComponent) [Complex:190361] Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:1112753] IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] [Homo sapiens] [Complex:1268183] Activated FGFR:p-FRS2:p-SHP2 [plasma membrane] [Homo sapiens] [Complex:1433530] p-SHP2:p-KIT complex [plasma membrane] [Homo sapiens] [Complex:2671749] LEP:p-LEPR:p-JAK2:p-SHP2 [plasma membrane] [Homo sapiens] [Complex:5654184] Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:5654198] Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:5654204] Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:5654271] Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] [Homo sapiens] [Complex:5654291] Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] [Homo sapiens]
(output) [Reaction:162558] Phosphorylation of SH-PTP2 protein [Homo sapiens]
(updatedInstance) [_UpdateTracker:9870646] Update Tracker - [EntityWithAccessionedSequence:162573] p-Y542,Y580-PTPN11 [cytosol] - v38:[modifyName] [_UpdateTracker:9874958] Update Tracker - [EntityWithAccessionedSequence:162573] p-Y542,Y580-PTPN11 [cytosol] - v44:[modifyEndCoordinate] [_UpdateTracker:9887236] Update Tracker - [EntityWithAccessionedSequence:162573] p-Y542,Y580-PTPN11 [cytosol] - v45:[addName] [_UpdateTracker:9904434] Update Tracker - [EntityWithAccessionedSequence:162573] p-Y542,Y580-PTPN11 [cytosol] - v84:[modifyName] [_UpdateTracker:9906534] Update Tracker - [EntityWithAccessionedSequence:162573] p-Y542,Y580-PTPN11 [cytosol] - v87:[modifyEndCoordinate]
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Pathways
No pathways have been reviewed or authored by p-Y542,Y580-PTPN11 [cytosol] (162573)