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Details on Person p-S295-PDE3B hydrolyses cAMP to AMP

Class:Id	Reaction:162425
_displayName	p-S295-PDE3B hydrolyses cAMP to AMP
_doRelease	TRUE
_timestamp	2017-11-22 16:10:03
catalystActivity	[CatalystActivity:162426] 3',5'-cyclic-nucleotide phosphodiesterase activity of p-S295-PDE3B [cytosol]
catalystActivityReference	[CatalystActivityReference:9643383] 3',5'-cyclic-nucleotide phosphodiesterase activity of p-S295-PDE3B [cytosol] Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:162424] de Bono, B, 2005-03-24 12:28:50
input	[SimpleEntity:30389] cAMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:162420] Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3) [LiteratureReference:162427] Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family) [LiteratureReference:9029739] From PDE3B to the regulation of energy homeostasis [LiteratureReference:9029750] The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
modified	[InstanceEdit:164887] de Bono, B, 2005-07-13 13:58:17 [InstanceEdit:389952] Jassal, Bijay, 2009-01-21 [InstanceEdit:3150160] Jupe, S, 2013-02-19 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9029767] Rothfels, Karen, 2017-11-22 [InstanceEdit:9029772] Rothfels, Karen, 2017-11-22 [InstanceEdit:9029782] Rothfels, Karen, 2017-11-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-S295-PDE3B hydrolyses cAMP to AMP
output	[SimpleEntity:76577] AMP [cytosol]
precedingEvent	[Reaction:162363] p-T309,S474-AKT2:PIP3 phosphorylates PDE3B [Homo sapiens] [Reaction:109702] PDPK1 phosphorylates AKT2 [Homo sapiens]
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361734] R-HSA-162425.5
summation	[Summation:178874] PDE3B hydrolyzes cAMP to AMP downstream of insulin signaling...
(hasEvent)	[Pathway:165160] PDE3B signalling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779715] Update Tracker - [Reaction:162425] p-S295-PDE3B hydrolyses cAMP to AMP - v64:[addLiteratureReference, modifyText] [_UpdateTracker:9791583] Update Tracker - [Reaction:162425] p-S295-PDE3B hydrolyses cAMP to AMP - v28:[addInput]
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