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Details on Person p-T309,S474-AKT2:PIP3 phosphorylates PDE3B

Class:Id	Reaction:162363
_displayName	p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
_doRelease	TRUE
_timestamp	2017-11-22 16:10:04
catalystActivity	[CatalystActivity:162362] protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:162358] de Bono, B, 2005-03-24 12:05:09
inferredFrom	[Reaction:162352] Phosphorylation of PDE3B by AKT-1 [Mus musculus]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [EntityWithAccessionedSequence:162348] PDE3B [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:9029735] Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase [LiteratureReference:162353] Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt [LiteratureReference:9027012] Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells [LiteratureReference:9029739] From PDE3B to the regulation of energy homeostasis
modified	[InstanceEdit:163145] de Bono, B, 2005-04-19 09:31:23 [InstanceEdit:164887] de Bono, B, 2005-07-13 13:58:17 [InstanceEdit:3150160] Jupe, S, 2013-02-19 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9029768] Rothfels, Karen, 2017-11-22 [InstanceEdit:9029773] Rothfels, Karen, 2017-11-22 [InstanceEdit:9029783] Rothfels, Karen, 2017-11-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:162419] p-S295-PDE3B [cytosol] [Homo sapiens]
precedingEvent	[Reaction:109702] PDPK1 phosphorylates AKT2 [Homo sapiens] [Reaction:109700] AKT2 binds PIP3 [Homo sapiens] [Reaction:109701] PDPK1 binds PIP3 [Homo sapiens]
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360765] R-HSA-162363.4
summation	[Summation:179068] Based on work done in mouse with AKT1, AKT2 is predicted to ...
(hasEvent)	[Pathway:165160] PDE3B signalling [Homo sapiens]
(precedingEvent)	[Reaction:162425] p-S295-PDE3B hydrolyses cAMP to AMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779880] Update Tracker - [Reaction:162363] p-T309,S474-AKT2:PIP3 phosphorylates PDE3B - v64:[addLiteratureReference, modifyText]
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