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Details on Person Excess cysteine yields lanthionine and H2S

Class:Id	Reaction:1614591
_displayName	Excess cysteine yields lanthionine and H2S
_doRelease	TRUE
_timestamp	2025-02-25 22:16:41
authored	[InstanceEdit:1237120] Stephan, R, 2010-10-24
catalystActivity	[CatalystActivity:1614529] carbon-sulfur lyase activity of PXLP-K212-CTH tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
crossReference	[DatabaseIdentifier:9929918] RHEA:68649
edited	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
input	[SimpleEntity:111707] L-Cys [cytosol] [SimpleEntity:111707] L-Cys [cytosol]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:1614602] H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia [LiteratureReference:1625216] Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration
modified	[InstanceEdit:1619464] Jassal, Bijay, 2011-09-30 [InstanceEdit:1625215] Jassal, Bijay, 2011-10-03 [InstanceEdit:1660488] Jassal, Bijay, 2011-10-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29 [InstanceEdit:9930119] D'Eustachio, Peter, 2024-12-02 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939357] D'Eustachio, Peter, 2025-02-25 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	Excess cysteine yields lanthionine and H2S 2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine
output	[SimpleEntity:1614582] L-Lanthionine [cytosol] [SimpleEntity:1614532] H2S [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:1614583] PXLP-K212-CTH cleaves L-Cystathionine [Homo sapiens] [Reaction:1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:1655888] Positive regulation by 'L-Cys [cytosol]'
releaseDate	2011-12-06
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016687] R-HSA-1614591.5
structureModified	[InstanceEdit:9929919] D'Eustachio, Peter, 2024-11-29
summation	[Summation:9939358] Excess cysteine will change the enzymatic activity of CBS su...
(hasEvent)	[Pathway:1614558] Degradation of cysteine and homocysteine [Homo sapiens]
(precedingEvent)	[Reaction:1614665] SQR oxidizes sulfide to bound persulfide [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939809] Update Tracker - [Reaction:1614591] Excess cysteine yields lanthionine and H2S - v92:[add_removeSummation, removeOutput]
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