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Details on Person PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine

Class:Id	Reaction:1614524
_displayName	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine
_doRelease	TRUE
_timestamp	2024-11-27 22:46:13
authored	[InstanceEdit:1237120] Stephan, R, 2010-10-24
catalystActivity	[CatalystActivity:1614644] cystathionine beta-synthase activity of PXLP-K119-CBS tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
crossReference	[DatabaseIdentifier:9929681] RHEA:10113
edited	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
input	[SimpleEntity:174369] HCYS [cytosol] [SimpleEntity:200736] L-Ser [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1614572] Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region [LiteratureReference:9644844] Binding of pyridoxal 5'-phosphate to the heme protein human cystathionine beta-synthase
modified	[InstanceEdit:1614779] Jassal, B, 2011-09-30 [InstanceEdit:1619464] Jassal, Bijay, 2011-09-30 [InstanceEdit:1660488] Jassal, Bijay, 2011-10-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9644847] Jassal, Bijay, 2019-04-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929687] D'Eustachio, Peter, 2024-11-27
name	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine L-homocysteine + L-serine => H2O + L,L-cystathionine
output	[SimpleEntity:1614518] L-Cystathionine [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Homo sapiens] [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP [Homo sapiens] [Reaction:175976] TMT transfers CH3 from AdoMet to BME [Homo sapiens] [Reaction:175987] NNMT transfers CH3 from AdoMet to PY [Homo sapiens] [Reaction:175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016440] R-HSA-1614524.5
summation	[Summation:1614514] The first step of homocysteine conversion to cysteine is cat...
(hasEvent)	[Pathway:1614603] Cysteine formation from homocysteine [Homo sapiens]
(precedingEvent)	[Reaction:1614583] PXLP-K212-CTH cleaves L-Cystathionine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777792] Update Tracker - [Reaction:1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine - v69:[addLiteratureReference, modifyText]
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