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Details on Person ASAH1 hydrolyzes ceramide

Class:Id	Reaction:1606602
_displayName	ASAH1 hydrolyzes ceramide
_doRelease	TRUE
_timestamp	2023-08-17 14:45:19
authored	[InstanceEdit:1606607] Jassal, B, 2011-09-23
catalystActivity	[CatalystActivity:1606585] N-acylsphingosine amidohydrolase activity of ASAH1 [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:1606607] Jassal, B, 2011-09-23
edited	[InstanceEdit:1606607] Jassal, B, 2011-09-23
input	[SimpleEntity:1605673] CERA [lysosomal lumen] [SimpleEntity:1605715] H2O [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:1606605] Purification, characterization, and biosynthesis of human acid ceramidase [LiteratureReference:1606579] Human acid ceramidase gene: novel mutations in Farber disease [LiteratureReference:1606593] Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease [LiteratureReference:9841165] Structural and membrane-binding properties of saposin D [LiteratureReference:9842013] Structural basis for the activation of acid ceramidase
modified	[InstanceEdit:1638092] Jassal, B, 2011-10-07 [InstanceEdit:1660664] Jassal, B, 2011-10-14 [InstanceEdit:1660680] Jassal, B, 2011-10-14 [InstanceEdit:1861756] Jassal, B, 2011-10-31 [InstanceEdit:1863069] Jassal, Bijay, 2011-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841164] Stephan, Ralf, 2023-08-10 [InstanceEdit:9841793] Stephan, Ralf, 2023-08-12 [InstanceEdit:9842010] Stephan, Ralf, 2023-08-16 [InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
name	ASAH1 hydrolyzes ceramide
output	[SimpleEntity:1606588] SPG [lysosomal lumen] [SimpleEntity:1861779] RCOO- [lysosomal lumen]
precedingEvent	[Reaction:1606564] GALC hydrolyzes GalCer [Homo sapiens] [Reaction:1606807] ARSA removes sulfate from PSAP(195-273):Sulfatide [Homo sapiens] [Reaction:9841189] GLA hydrolyzes PSAP(195-273):Gal2Cer:PE [Homo sapiens] [BlackBoxEvent:9840334] PSAP is cleaved [Homo sapiens] [Reaction:1605797] SMPD1 hydrolyzes SPHM [Homo sapiens] [Reaction:1605591] GBA1:SAPC hydrolyzes GlcCer [Homo sapiens] [Reaction:1606312] GLB1 hydrolyzes SapB/C:LacCer [Homo sapiens] [BlackBoxEvent:9840334] PSAP is cleaved [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[Requirement:9841168] Requirement by 'PSAP(405-486) [lysosomal lumen]'
regulationReference	[RegulationReference:9841167] Requirement by 'PSAP(405-486) [lysosomal lumen]' Structural and membrane-binding properties of saposin D
releaseDate	2011-12-06
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31 [InstanceEdit:9842094] D'Eustachio, Peter, 2023-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016477] R-HSA-1606602.3
structureModified	[InstanceEdit:9841164] Stephan, Ralf, 2023-08-10
summation	[Summation:1606598] Acid ceramidase (ASAH1) is a lysosomal enzyme that catalyses...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9842268] Update Tracker - [Reaction:1606602] ASAH1 hydrolyzes ceramide - v86:[addLiteratureReference, addRegulator, modifyText]
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