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Details on Person ASAH2 hydrolyzes ceramide (plasma membrane)

Class:Id	Reaction:1606583
_displayName	ASAH2 hydrolyzes ceramide (plasma membrane)
_doRelease	TRUE
_timestamp	2023-08-12 13:15:25
authored	[InstanceEdit:1606607] Jassal, B, 2011-09-23
catalystActivity	[CatalystActivity:1606595] N-acylsphingosine amidohydrolase activity of ASAH2-like proteins [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1606607] Jassal, B, 2011-09-23
edited	[InstanceEdit:1606607] Jassal, B, 2011-09-23
input	[SimpleEntity:429807] CERA [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1606587] Subcellular localization of human neutral ceramidase expressed in HEK293 cells [LiteratureReference:1861786] Identification of a novel amidase motif in neutral ceramidase
modified	[InstanceEdit:1638092] Jassal, B, 2011-10-07 [InstanceEdit:1640172] Jassal, Bijay, 2011-10-10 [InstanceEdit:1861756] Jassal, B, 2011-10-31 [InstanceEdit:1863069] Jassal, Bijay, 2011-10-31 [InstanceEdit:1864087] Jassal, B, 2011-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841226] Stephan, Ralf, 2023-08-11 [InstanceEdit:9841793] Stephan, Ralf, 2023-08-12
name	ASAH2 hydrolyzes ceramide (plasma membrane)
output	[SimpleEntity:1606609] SPG [plasma membrane] [SimpleEntity:1861754] RCOO- [cytosol]
precedingEvent	[Reaction:1640164] ENPP7 hydrolyzes sphingomyelin [Homo sapiens] [Reaction:429786] SGMS2 transfers phosphocholine onto ceramide [Homo sapiens] [Reaction:1861788] GBA2 hydrolyzes GlcCer (plasma membrane) [Homo sapiens] [Reaction:1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) [Homo sapiens] [Reaction:429786] SGMS2 transfers phosphocholine onto ceramide [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016460] R-HSA-1606583.3
summation	[Summation:1606606] Neutral ceramidase (ASAH2) is an enzyme localised to the pla...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
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No pathways have been reviewed or authored by ASAH2 hydrolyzes ceramide (plasma membrane) (1606583)