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Details on Person MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA

Class:Id	Reaction:1606561
_displayName	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
_doRelease	TRUE
_timestamp	2024-11-08 15:09:22
authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1606560] Orlic-Milacic, M, 2011-09-22
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2121209] May, B, 2012-02-09 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06 [InstanceEdit:1609686] Jupe, S, 2011-09-27 [InstanceEdit:2121211] Gillespie, ME, 2012-02-09
input	[EntityWithAccessionedSequence:1606559] NOTCH1 mRNA [cytosol] [Homo sapiens] [DefinedSet:1606557] miR-449 RISC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
modified	[InstanceEdit:1985685] Orlic-Milacic, M, 2011-11-11 [InstanceEdit:2023189] Orlic-Milacic, M, 2011-12-06 [InstanceEdit:2029532] Orlic-Milacic, M, 2012-01-04 [InstanceEdit:2032332] Orlic-Milacic, M, 2012-01-06 [InstanceEdit:2121213] Orlic-Milacic, M, 2012-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9927655] Orlic-Milacic, Marija, 2024-11-08
name	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
negativePrecedingEvent	[NegativePrecedingEvent:9927649] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
output	[Complex:1606562] NOTCH1 mRNA:miR-449 RISC [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1912416] NOTCH1 gene transcription [Homo sapiens] [Reaction:4395227] CCND1:CREBBP binds NOTCH1 promoter [Homo sapiens] [Reaction:4395231] E2F1/3:DP1/2 binds NOTCH1 promoter [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158185] R-HSA-1606561.3
summation	[Summation:1606558] Translation of NOTCH1 mRNA is negatively regulated by MIR449...
(hasEvent)	[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9949534] miR-449 and miR-34 repress NOTCH1 mRNA translation [Homo sapiens]
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No pathways have been reviewed or authored by MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA (1606561)