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Details on Person Recruitment of IRF3 to activated ZBP1:TBK1

Class:Id	Reaction:1606345
_displayName	Recruitment of IRF3 to activated ZBP1:TBK1
_doRelease	TRUE
_timestamp	2022-02-14 06:55:04
authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1606339] Shamovsky, V, 2011-09-21
edited	[InstanceEdit:2134527] Shamovsky, V, 2012-02-23
inferredFrom	[Reaction:1810458] Recruitment of Irf3 to activated Dai:Tbk1 [Mus musculus]
input	[EntityWithAccessionedSequence:166251] IRF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166251] IRF3 [cytosol] [Homo sapiens] [Complex:1606333] dsDNA:ZBP1:pS-172-TBK1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1591232] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
modified	[InstanceEdit:1810478] Shamovsky, V, 2011-10-25 [InstanceEdit:2122961] Shamovsky, V, 2012-02-14 [InstanceEdit:2129343] Shamovsky, V, 2012-02-19 [InstanceEdit:2143411] Shamovsky, V, 2012-02-24 [InstanceEdit:3604377] Shamovsky, V, 2013-05-22 [InstanceEdit:9013860] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9691185] Jassal, Bijay, 2020-06-09 [InstanceEdit:9764711] Shamovsky, Veronica, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of IRF3 to activated ZBP1:TBK1
negativePrecedingEvent	[NegativePrecedingEvent:9764710] Futile Cycle: Phosphorylation and release of IRF3
output	[Complex:1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation [Homo sapiens] [Reaction:1591234] ZBP1 binds cytosolic DNA [Homo sapiens]
regulatedBy	[NegativeRegulation:9691186] Negative regulation by 'TBK1:amlexanox [cytosol]'
relatedSpecies	[Species:8982084] Human alphaherpesvirus 2 [Species:2671791] Human cytomegalovirus
releaseDate	2012-03-13
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158043] R-HSA-1606345.5
summation	[Summation:1810471] ZBP1 (DAI) dimer formation enables recruitment of TBK1 and I...
(hasEvent)	[Pathway:1606341] IRF3 mediated activation of type 1 IFN [Homo sapiens]
(precedingEvent)	[Reaction:1606327] Phosphorylation and release of IRF3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776785] Update Tracker - [Reaction:1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - v74:[addRegulator] [_UpdateTracker:9787423] Update Tracker - [Reaction:1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - v45:[modifyText]
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