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Details on Person Phosphorylation and release of IRF3

Class:Id	Reaction:1606327
_displayName	Phosphorylation and release of IRF3
_doRelease	TRUE
_timestamp	2017-07-26 05:42:56
authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1606339] Shamovsky, V, 2011-09-21
edited	[InstanceEdit:2134527] Shamovsky, V, 2012-02-23
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:434014] Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch [LiteratureReference:433975] Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
modified	[InstanceEdit:1810478] Shamovsky, V, 2011-10-25 [InstanceEdit:2032397] Shamovsky, V, 2012-01-06 [InstanceEdit:2054086] Shamovsky, V, 2012-01-12 [InstanceEdit:2122961] Shamovsky, V, 2012-02-14 [InstanceEdit:2129343] Shamovsky, V, 2012-02-19 [InstanceEdit:2143411] Shamovsky, V, 2012-02-24 [InstanceEdit:2396013] Shamovsky, V, 2012-07-09 [InstanceEdit:9013845] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation and release of IRF3
output	[Complex:1606333] dsDNA:ZBP1:pS-172-TBK1 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [EntityWithAccessionedSequence:166258] p-4S,T404-IRF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166258] p-4S,T404-IRF3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1606345] Recruitment of IRF3 to activated ZBP1:TBK1 [Homo sapiens] [Reaction:1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation [Homo sapiens]
regulatedBy	[NegativeRegulation:3249373] Negative regulation by 'NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]'
regulationReference	[RegulationReference:9641587] Negative regulation by 'NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]' NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
relatedSpecies	[Species:8982084] Human alphaherpesvirus 2 [Species:2671791] Human cytomegalovirus
releaseDate	2012-03-13
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158115] R-HSA-1606327.5
summation	[Summation:2054083] IRF3 is activated through a two-step phosphorylation in the ...
(hasEvent)	[Pathway:1606341] IRF3 mediated activation of type 1 IFN [Homo sapiens]
(precedingEvent)	[Reaction:2395992] p-T,4S-IRF3 is dimerized [Homo sapiens] [NegativePrecedingEvent:9764705] Negative relationship: Phosphorylation and release of IRF3 [NegativePrecedingEvent:9764710] Futile Cycle: Phosphorylation and release of IRF3 [NegativePrecedingEvent:9764717] Drug molecule: Phosphorylation and release of IRF3
(updatedInstance)	[_UpdateTracker:9787439] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v45:[addRegulator] [_UpdateTracker:9788482] Update Tracker - [Reaction:1606327] Phosphorylation and release of IRF3 - v42:[add_removeOutput]
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