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Details on Person SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)

Class:Id	Reaction:1606273
_displayName	SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)
_doRelease	TRUE
_timestamp	2023-08-17 14:45:51
authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1606275] sphingomyelin phosphodiesterase activity of SMPD2,3:Mg2+ [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1606271] Jassal, Bijay, 2011-09-21
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
input	[SimpleEntity:429776] SPHM d18:1 [plasma membrane] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:194383] Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? [LiteratureReference:1606274] Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase [LiteratureReference:1606270] Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism
modified	[InstanceEdit:1606314] Jassal, Bijay, 2011-09-21 [InstanceEdit:1606563] Jassal, Bijay, 2011-09-23 [InstanceEdit:1610734] Jassal, Bijay, 2011-09-27 [InstanceEdit:1640172] Jassal, Bijay, 2011-10-10 [InstanceEdit:1863069] Jassal, Bijay, 2011-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841226] Stephan, Ralf, 2023-08-11 [InstanceEdit:9841793] Stephan, Ralf, 2023-08-12 [InstanceEdit:9842060] Stephan, Ralf, 2023-08-17 [InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
name	SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)
output	[SimpleEntity:429807] CERA [plasma membrane] [SimpleEntity:1610735] ChoP [plasma membrane] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:429786] SGMS2 transfers phosphocholine onto ceramide [Homo sapiens] [Reaction:1640164] ENPP7 hydrolyzes sphingomyelin [Homo sapiens] [Reaction:1861788] GBA2 hydrolyzes GlcCer (plasma membrane) [Homo sapiens] [Reaction:1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-12-06
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31 [InstanceEdit:9842094] D'Eustachio, Peter, 2023-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016423] R-HSA-1606273.3
structureModified	[InstanceEdit:9842060] Stephan, Ralf, 2023-08-17
summation	[Summation:1606267] The mammalian brain-specific, Mg2+-dependent, neutral sphing...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(precedingEvent)	[Reaction:429786] SGMS2 transfers phosphocholine onto ceramide [Homo sapiens] [Reaction:1606583] ASAH2 hydrolyzes ceramide (plasma membrane) [Homo sapiens] [Reaction:1638845] CERK phosphorylates CERA to form C1P [Homo sapiens] [Reaction:6785933] UGT8 transfers Gal from UDP-Gal to CERA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9842307] Update Tracker - [Reaction:1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - v86:[addOutput]
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