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Details on Person NEU2 cleaves GM3 to form LacCer (cytosol)

Class:Id	Reaction:1605723
_displayName	NEU2 cleaves GM3 to form LacCer (cytosol)
_doRelease	TRUE
_timestamp	2023-08-12 13:16:43
authored	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
catalystActivity	[CatalystActivity:1605672] exo-alpha-sialidase activity of NEU2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
edited	[InstanceEdit:1605804] Jassal, Bijay, 2011-09-21
input	[SimpleEntity:1605590] GM3 [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1605663] Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases
modified	[InstanceEdit:1605814] Jassal, B, 2011-09-21 [InstanceEdit:1606563] Jassal, Bijay, 2011-09-23 [InstanceEdit:1863069] Jassal, Bijay, 2011-10-31 [InstanceEdit:4085381] Jassal, B, 2013-08-05 [InstanceEdit:4085400] Jassal, B, 2013-08-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9841226] Stephan, Ralf, 2023-08-11 [InstanceEdit:9841793] Stephan, Ralf, 2023-08-12
name	NEU2 cleaves GM3 to form LacCer (cytosol)
output	[SimpleEntity:428633] Neu5Ac [cytosol] [SimpleEntity:1605647] LacCer [cytosol]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1863068] Stephan, Ralf, 2011-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016472] R-HSA-1605723.3
summation	[Summation:1605783] Sialidase-2 (NEU2) hydrolyses Neu5Ac from GM3 in the cytosol...
(hasEvent)	[Pathway:9840310] Glycosphingolipid catabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787049] Update Tracker - [Reaction:1605723] Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol) - v46:[add_removeOutput]
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