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Details on Person FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]

Class:Id	Complex:1604469
_displayName	FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
_timestamp	2012-03-01 11:46:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1604466] Orlic-Milacic, M, 2011-09-15
hasComponent	[EntityWithAccessionedSequence:187538] SKP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1234142] RBX1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:187551] CUL1 [nucleoplasm] [Homo sapiens] [CandidateSet:1602299] FBXW7alpha/gamma [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2022817] Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line [LiteratureReference:2064874] FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
modified	[InstanceEdit:2022837] May, B, 2011-12-01 [InstanceEdit:2064876] Orlic-Milacic, M, 2012-01-19
name	FBXW7:SKP1:CUL1:RBX1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2159139] R-HSA-1604469.1
(hasComponent)	[Complex:1604468] p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [Homo sapiens] [Complex:2022833] SREBF:SCFbw7:CDC34:Ubiquitin [nucleoplasm] [Homo sapiens] [Complex:2064852] p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [Homo sapiens] [Complex:2220955] p-NICD1 PEST domain mutants:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [Homo sapiens]
(input)	[Reaction:1912385] Phosphorylated NICD1 binds FBXW7 [Homo sapiens] [Reaction:2022843] FBW7 Binds p-SREBP [Homo sapiens] [Reaction:2064853] FBXW7 binds phosphorylated NICD1 [Homo sapiens] [FailedReaction:2220967] p-NICD1 PEST domain mutants do not bind FBXW7 [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:2642421] loss_of_function of FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm]
(output)	[Reaction:1852623] Ubiquitination of NICD1 by FBWX7 [Homo sapiens] [Reaction:2064883] FBXW7 mediates ubiquitination of phosphorylated NICD1 [Homo sapiens]
(physicalEntity)	[CatalystActivity:9604630] ubiquitin protein ligase activity of FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
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No pathways have been reviewed or authored by FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (1604469)