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Details on Person MMP2 can be activated by MMP1 (Crabbe et al. 1994a, Sang et ...

Class:IdSummation:1604351
_displayNameMMP2 can be activated by MMP1 (Crabbe et al. 1994a, Sang et ...
_timestamp2012-02-28 16:01:54
created[InstanceEdit:1604374] Jupe, S, 2011-09-15
literatureReference[LiteratureReference:1592283] Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A
[LiteratureReference:1604353] Activation of human progelatinase A by collagenase and matrilysin: activation of procollagenase by matrilysin
[LiteratureReference:1604342] Human progelatinase A can be activated by matrilysin
[LiteratureReference:1604354] Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties
[LiteratureReference:1454834] A matrix metalloproteinase expressed on the surface of invasive tumour cells
[LiteratureReference:1592360] Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases
[LiteratureReference:2157500] Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway
[LiteratureReference:1592356] Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family
modified[InstanceEdit:1629854] Jupe, S, 2011-10-04
[InstanceEdit:2157501] Jupe, S, 2012-02-28
textMMP2 can be activated by MMP1 (Crabbe et al. 1994a, Sang et al. 1996) and MMP7 (Crabbe et al. 1994b, Sang et al. 1996). MMP1 initially cleaves either Pro33-Ile34 or Asn66-Leu67. This is followed by autolytic cleavage at Asn109-Tyr110 (Crabbe et al. 1994a, Okada et al. 1990, Sang et al. 1996). MMP1 and MMP7 are not efficient activators of MMP2; significant physiological activation of proMMP2 is performed by the MT-MMPs MMP14 (Sato et al. 1994), MMP15 (Butler et al. 1997, Morrison et al. 2001) and MMP16 (Takino et al. 1995). Residue numbering here refers to the UniProt canonical sequence.
(summation)[Reaction:1604359] Initial activation of proMMP2 by MMP1, 7 [Homo sapiens]
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