Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person FBXW7alpha R505C [nucleoplasm]

Class:IdEntityWithAccessionedSequence:1602336
_displayNameFBXW7alpha R505C [nucleoplasm]
_timestamp2013-06-06 16:42:22
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:1602327] Orlic-Milacic, M, 2011-09-14
crossReference[DatabaseIdentifier:2220835] COSMIC:COSV55891274
[DatabaseIdentifier:2220834] COSMIC:COSM33844
disease[Disease:1485587] T-cell acute lymphoblastic leukemia
[Disease:1500689] cancer
endCoordinate707
hasModifiedResidue[ReplacedResidue:1602333] L-arginine 505 replaced with L-cysteine
literatureReference[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
modified[InstanceEdit:2220819] Orlic-Milacic, M, 2012-05-01
[InstanceEdit:2220837] Orlic-Milacic, M, 2012-05-01
[InstanceEdit:3450990] Jupe, S, 2013-05-16
[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
nameFBXW7alpha R505C
FBXW7alpha Arg505Cys
FBXW7-1 R505C
referenceEntity[ReferenceIsoform:412591] UniProt:Q969H0-1 FBXW7 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3202831] R-HSA-1602336.1
startCoordinate1
(hasMember)[CandidateSet:1602342] FBXW7 R505/387C mutant [nucleoplasm] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9886503] Update Tracker - [EntityWithAccessionedSequence:1602336] FBXW7alpha R505C [nucleoplasm] - v45:[addName]
[_UpdateTracker:9888402] Update Tracker - [EntityWithAccessionedSequence:1602336] FBXW7alpha R505C [nucleoplasm] - v46:[modifyName]
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No pathways have been reviewed or authored by FBXW7alpha R505C [nucleoplasm] (1602336)