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Details on Person UniProt:Q710E8 ORC1A
| Class:Id | ReferenceGeneProduct:1601071 |
|---|---|
| _chainChangeLog | chain:1-809 added on Sat February 7 2015 |
| _displayName | UniProt:Q710E8 ORC1A |
| _timestamp | 2024-08-09 18:45:36 |
| chain | chain:1-809 |
| checksum | 85698C9B8BF0AB42 |
| comment | FUNCTION Essential protein (PubMed:19171893). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that positively regulates the transcription of a subset of genes (PubMed:19171893).SUBUNIT Component of the origin recognition complex (ORC) composed of at least ORC1 (ORC1A or ORC1B), ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts directly with ORC2, ORC3, ORC4 and ORC5 (PubMed:15358564, PubMed:16179646). Binds mostly unmodified histone H3, and, with lower efficiency, H3K4me1 H3K4me2 and H3K4me3 (PubMed:26876097).INTERACTION Follow a cell-cycle regulation with a peak at the G1/S-phase (PubMed:16179646). Mostly expressed in siliques, flowers and flower buds, and, to a lower extent, in roots, leaves and stems (PubMed:15358564, PubMed:16179646).DEVELOPMENTAL STAGE Preferentially expressed in endoreplicating cells, such as cells of the apical hook of dark-grown seedlings.INDUCTION Regulated by E2F (PubMed:16179646). Accumulates rapidly after cell cycle reactivation by sucrose addition following cell cycle arrest mediated by sucrose deprivation (PubMed:15358564, PubMed:16179646).DISRUPTION PHENOTYPE Lethal.SIMILARITY Belongs to the ORC1 family. |
| created | [InstanceEdit:1598235] Couchman, M, 2007-07-04 |
| crossReference | [DatabaseIdentifier:1599729] ATIDB:At4g14700 [DatabaseIdentifier:1599727] TAIR:At4g14700 [DatabaseIdentifier:1600520] MIPS:At4g14700 [DatabaseIdentifier:1600521] NCBI Entrez Gene:At4g14700 [DatabaseIdentifier:1600522] TIGR:At4g14700 |
| description | recommendedName: fullName evidence="13"Origin of replication complex subunit 1A shortName evidence="13"AtORC1a alternativeName: fullName evidence="15"Origin recognition complex subunit 1a |
| geneName | ORC1A At4g14700 dl3390w FCAALL.93 |
| identifier | Q710E8 |
| isSequenceChanged | FALSE |
| keyword | Activator ATP-binding DNA replication DNA-binding Magnesium Metal-binding Nucleotide-binding Nucleus Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | ORC1A |
| otherIdentifier | Q710E8_ARATH Q710E8 254824_s_at AT4G14700 _ARATH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ORC1A_ARATH O23326 Q94G49 |
| sequenceLength | 809 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599057] orc1a (gene) [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599190] ORC1a [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q710E8 ORC1A (1601071)
