Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9ZQ19 RPA2A
| Class:Id | ReferenceGeneProduct:1601038 |
|---|---|
| _chainChangeLog | chain:1-279 for 1601038 added on Fri Nov 03 2023 |
| _displayName | UniProt:Q9ZQ19 RPA2A |
| _timestamp | 2023-11-03 18:38:37 |
| chain | chain:1-279 |
| checksum | 3DD5B70FE6FC5736 |
| comment | FUNCTION Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Required fo cell division in meristems. Involved in the maintenance of transcriptional epigenetic gene silencing (TGS) at specific loci (including some transposons) by regulating histone H3 acetylation, 'Lys-4' and 'Lys-9' methylation.SUBUNIT Heterotrimer of RPA1, RPA2 and RPA3 (canonical replication protein A complex) (By similarity). Interacts with ROS1. Binds to ASE1/At3g02920, PDX2, At5g62350, RPA1A/At2g06510, ARF1/At1g10630, At4g18590 and At3g52630.SUBCELLULAR LOCATION Redistributes to discrete nuclear foci upon DNA damage.TISSUE SPECIFICITY Strongly expressed in shoot and root meristems. Present in seedlings, roots, leaves, siliques and flowers.DEVELOPMENTAL STAGE Accumulates essentially in meristematic active tissues. In seedlings, expressed in primary roots, shoot apical meristems (SAMs), cotyledons, and vascular tissues. Later observed in lateral root primordia, root tips, SAMs and young leaves.PTM Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). In response to DNA damage, recruited to DNA-repair nuclear foci, as a hypophosphorylated form (By similarity).DISRUPTION PHENOTYPE Affected cell division in meristems but normal final cell sizes. Earlier flowering and smaller plant size. Enhanced sensitivity to methyl methanesulfonate (MMS), a genotoxic agent that damages DNA bases. Enhanced expression of some transposons. When associated with ROS1 disruption, restored silencing of some genes associated with increased histone H3 acetylation and histone H3 'Lys-4' methylation (H3K4me2), but decreased histone H3 'Lys-9' methylation (H3K9me2) in their promoter.SIMILARITY Belongs to the replication factor A protein 2 family. |
| created | [InstanceEdit:1598120] Couchman, M, 2007-07-02 |
| crossReference | [DatabaseIdentifier:1600451] ATIDB:At2g24490 [DatabaseIdentifier:1600452] TAIR:At2g24490 [DatabaseIdentifier:1600453] MIPS:At2g24490 [DatabaseIdentifier:1600454] NCBI Entrez Gene:At2g24490 [DatabaseIdentifier:1600455] TIGR:At2g24490 |
| description | recommendedName: Replication protein A 32 kDa subunit A shortName: AtRPA32A shortName: RP-A p32 A alternativeName: DNA replication protein A2 subunit A alternativeName: Protein SUPPRESSOR OF ROS1 alternativeName: Replication factor A protein 2 A shortName: AtRPA2 A shortName: RF-A protein 2 A alternativeName: Replicon protein A2 A |
| geneName | RPA2A ROR1 RPA32A At2g24490 T28I24.22 |
| identifier | Q9ZQ19 |
| isSequenceChanged | FALSE |
| keyword | DNA damage DNA recombination DNA repair DNA replication DNA-binding Nucleus Phosphoprotein Reference proteome |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | RPA2A |
| otherIdentifier | Q9ZQ19_ARATH Q9ZQ19 265695_at AT2G24490 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RFA2A_ARATH |
| sequenceLength | 279 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599251] RPA2A [Arabidopsis thaliana] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9ZQ19 RPA2A (1601038)
