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Details on Person UniProt:Q2V419 CDKB1-2

Class:Id	ReferenceGeneProduct:1601033
_chainChangeLog	chain:1-311 added on Sat February 7 2015
_displayName	UniProt:Q2V419 CDKB1-2
_timestamp	2025-02-21 19:16:27
chain	chain:1-311
checksum	A04E60AEF83E5BB0
comment	FUNCTION Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata (PubMed:20675570). In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage (PubMed:24123248).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)SUBUNIT Interacts with CKS1.ALTERNATIVE PRODUCTS Expressed in flowers.DISRUPTION PHENOTYPE No apparent stomatal abnormalities. The double mutant cdkb1;1 cdkb1;2 has a reduced number of abnormal stomata consisting in single guard cells (GC) (PubMed:20675570). The quadruple mutant flp-1 myb88 cdkb1;1 cdkb1;2 has a reduced number of large single guard cells blocked at mitosis, with strongly altered shape and size and characterized by enlarged nucleus due to endomitosis and endocycling, as well as extensive chloroplast replication (PubMed:24123248).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SEQUENCE CAUTION Truncated C-terminus.
created	[InstanceEdit:1597970] Couchman, M, 2007-07-03
crossReference	[DatabaseIdentifier:1600442] ATIDB:AT2G38620 [DatabaseIdentifier:1600443] TAIR:AT2G38620 [DatabaseIdentifier:1600444] MIPS:AT2G38620 [DatabaseIdentifier:1600445] NCBI Entrez Gene:AT2G38620 [DatabaseIdentifier:1600446] TIGR:AT2G38620 [DatabaseIdentifier:1600446] TIGR:AT2G38620
description	recommendedName: Cyclin-dependent kinase B1-2 shortName: CDKB1;2 ecNumber: 2.7.11.22 ecNumber: 2.7.11.23
geneName	CDKB1-2 At2g38620 T6A23.18
identifier	Q2V419
isSequenceChanged	FALSE
keyword	Alternative splicing ATP-binding Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase
modified	[InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	CDKB1-2
otherIdentifier	AT2G38620 Q56XK5_ARATH Q56XK5 Q2V419_ARATH Q2V419 Q9ZVI4_ARATH Q9ZVI4 266401_s_at
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	CKB12_ARATH Q56XK5 Q9ZVI4
sequenceLength	311
species	[Species:170905] Arabidopsis thaliana
(isoformParent)	[ReferenceIsoform:8970930] UniProt:Q2V419-1 CDKB1-2 [Arabidopsis thaliana] [ReferenceIsoform:8970931] UniProt:Q2V419-2 CDKB1-2 [Arabidopsis thaliana]
(referenceEntity)	[EntityWithAccessionedSequence:1599191] CDKB1;2 [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599239] CDKB1;2-phosphorylated(Thr160) [nucleoplasm] [Arabidopsis thaliana]
(referenceSequence)	[ModifiedResidue:1600816] phosphate [nucleoplasm] on ChEBI:32835 threonine residue 160 of UNIPROT:Q56XK5_ARATH Putative cell division control protein kinase
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No pathways have been reviewed or authored by UniProt:Q2V419 CDKB1-2 (1601033)