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Details on Person UniProt:Q9SF37 MCM8
| Class:Id | ReferenceGeneProduct:1600999 |
|---|---|
| _chainChangeLog | chain:1-801 added on Sat February 7 2015 |
| _displayName | UniProt:Q9SF37 MCM8 |
| _timestamp | 2026-02-20 21:51:00 |
| chain | chain:1-801 |
| checksum | 811B5AA36E2D58C9 |
| comment | FUNCTION Probable DNA helicase that plays a role in meiotic double-strand break (DSB) repair, but does not seem to be required for recombination with the homologous chromosome (PubMed:23300481). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (By similarity). May be involved with RAD51 in a backup pathway that repairs meiotic DSB without giving meiotic crossover, in parallel to meiotic homologous recombination which relies on DMC1 (PubMed:23300481).CATALYTIC ACTIVITY Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)COFACTOR Binds 1 Zn(2+) ion per subunit.SUBUNIT Component of the heterohexameric MCM8-MCM9 complex.SUBCELLULAR LOCATION Reduced fertility and seed numbers due to defects in gametogenesis.SIMILARITY Belongs to the MCM family. |
| created | [InstanceEdit:1598120] Couchman, M, 2007-07-02 |
| crossReference | [DatabaseIdentifier:1600354] ATIDB:At3g09660 [DatabaseIdentifier:1600355] TAIR:At3g09660 [DatabaseIdentifier:1600356] MIPS:At3g09660 [DatabaseIdentifier:1600357] NCBI Entrez Gene:At3g09660 [DatabaseIdentifier:1600358] TIGR:At3g09660 |
| description | recommendedName: Probable DNA helicase MCM8 ecNumber evidence="2"5.6.2.4 alternativeName: Minichromosome maintenance 8 shortName: AtMCM8 alternativeName: fullName evidence="6"Probable DNA 3'-5' helicase MCM8 |
| geneName | MCM8 At3g09660 F11F8.25 |
| identifier | Q9SF37 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell cycle DNA damage DNA repair DNA replication DNA-binding Helicase Hydrolase Isomerase Meiosis Metal-binding Nucleotide-binding Nucleus Reference proteome Zinc Zinc-finger |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | MCM8 |
| otherIdentifier | Q9SF37_ARATH Q9SF37 258697_at AT3G09660 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MCM8_ARATH L7UY20 |
| sequenceLength | 801 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599092] mcm8 (gene) [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599223] tert (gene) [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599300] MCM8 [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599430] TERT [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q9SF37 MCM8 (1600999)
