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Details on Person UniProt:O80536 PIF3
| Class:Id | ReferenceGeneProduct:1600965 |
|---|---|
| _chainChangeLog | chain:1-524 added on Fri February 6 2015 |
| _displayName | UniProt:O80536 PIF3 |
| _timestamp | 2024-08-09 18:55:10 |
| chain | chain:1-524 |
| checksum | 1044AC01D598DE7C |
| comment | FUNCTION Transcription factor acting in the phytochrome signaling pathway (PubMed:10466729, PubMed:14508006). Activates transcription by binding to the G box (5'-CACGTG-3'), particularly in the dark but barely in far-red light (PubMed:10797009, PubMed:31732705). Acts as a negative regulator of phytochrome B signaling (PubMed:14508006). Represses chlorophyll biosynthesis and photosynthesis in the dark (PubMed:23548744). Recruits the histone deacetylase HDA15 to the promoters of chlorophyll biosynthetic and photosynthetic genes (PubMed:23548744). HDA15 represses their transcription by histone deacetylation (PubMed:23548744). Promotes the expression of MDP60 to modulate hypocotyl cell elongation in response to light and ethylene signaling (PubMed:29167353). Required for submergence-induced and ethylene-dependent underwater hypocotyl elongation (PubMed:31638649).ACTIVITY REGULATION Sequestered by PhyA from its target genes promoters in far-red light.SUBUNIT Homodimer (PubMed:25944101). Can form a heterodimer with REP1 and PIF4. Phytochrome B binds specifically to DNA-bound PIF3, but only upon red light induced conversion to the Pfr form (PfrB). Reconversion to Pr form causes rapid dissociation. Interacts with APRR1/TOC1. Binds to PIA2; this interaction may trigger the repression of PHYA-mediated phosphorylation (PubMed:27143545). Interacts with TOPP4 (Probable) (PubMed:11828023, PubMed:12826627, PubMed:12897250, PubMed:26704640, PubMed:27143545). Interacts with FYPP1 and FYPP3 (PubMed:31527236). Interacts with HDA15 in the dark (PubMed:23548744). Associates to PTAC12/HMR/PAP5 which acts as a transcriptional coactivator (PubMed:25944101). Binds to PhyA (PubMed:31732705).INTERACTION Expressed in stems, leaves, seedlings, fruits and flowers, and, to a lower extent, in roots.DEVELOPMENTAL STAGE Accumulates progressively in maturating seeds to reach a peak in dry seeds (PubMed:23708772). Expressed upon seed imbibition (PubMed:23708772).INDUCTION By UV treatment (PubMed:12679534). Repressed by red (R) and far red (FR) light treatments in a phyB- and phyA-dependent manner, and via a PTAC12/HMR/PAP5 regulated process (PubMed:25944101). Up-regulated by abscisic acid (ABA), ethylene (ACC), auxin (IAA), salt (NaCl), cold and heat (PubMed:23708772). Follows a tenous circadian rhythm with slightly higher levels at the end of the light phase (PubMed:23708772).PTM Phosphorylated by PHYA; this phosphorylation is repressed by PIA2.PTM Dephosphorylated by TOPP4 during photomorphogenesis, leading to subsequent degradation of PIF3 by the proteasomal pathway.DISRUPTION PHENOTYPE Inhibited submergence-induced and ethylene-dependent underwater hypocotyl elongation. |
| created | [InstanceEdit:1601927] Preece, J, 2011-09-12 |
| description | recommendedName: fullName evidence="22"Transcription factor PIF3 alternativeName: fullName evidence="20"Basic helix-loop-helix protein 8 shortName evidence="20"AtbHLH8 shortName evidence="20"bHLH 8 alternativeName: fullName evidence="22"Phytochrome-associated protein 3 alternativeName: fullName evidence="21"Phytochrome-interacting factor 3 alternativeName: fullName evidence="22"Transcription factor EN 100 alternativeName: fullName evidence="22"bHLH transcription factor bHLH008 |
| geneName | PIF3 BHLH8 EN100 PAP3 At1g09530 F14J9.19 |
| identifier | O80536 |
| isSequenceChanged | FALSE |
| keyword | DNA-binding Nucleus Phosphoprotein Phytochrome signaling pathway Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | PIF3 |
| otherIdentifier | AT1G09530 O80536 O80536_ARATH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PIF3_ARATH A5Y7A2 A5Y7A3 A5Y7A4 A5Y7A5 A5Y7A6 A5Y7A7 A5Y7A8 A5Y7A9 A5Y7B0 A5Y7B1 A5Y7B2 A5Y7B3 A5Y7B4 A5Y7B5 A5Y7B6 Q9SBC5 |
| sequenceLength | 524 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599059] phospho-PIF3 [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599457] PIF3 [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:O80536 PIF3 (1600965)
