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Details on Person UniProt:O65251 FEN1
| Class:Id | ReferenceGeneProduct:1600940 |
|---|---|
| _chainChangeLog | chain:1-383 for 1600940 added on Fri Nov 03 2023 |
| _displayName | UniProt:O65251 FEN1 |
| _timestamp | 2023-11-03 18:39:07 |
| chain | chain:1-383 |
| checksum | D209B33E09B3A252 |
| comment | FUNCTION Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.COFACTOR Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.SUBUNIT Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.SUBCELLULAR LOCATION Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.ALTERNATIVE PRODUCTS A number of isoforms are produced. According to EST sequences.PTM Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.SIMILARITY Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily. |
| created | [InstanceEdit:1598235] Couchman, M, 2007-07-04 |
| crossReference | [DatabaseIdentifier:1600183] ATIDB:At5g26680 [DatabaseIdentifier:1600184] TAIR:At5g26680 [DatabaseIdentifier:1600185] MIPS:At5g26680 [DatabaseIdentifier:1600186] NCBI Entrez Gene:At5g26680 [DatabaseIdentifier:1600187] TIGR:At5g26680 |
| description | recommendedName: fullName evidence="1"Flap endonuclease 1 shortName evidence="1"FEN-1 ecNumber evidence="1"3.1.-.- alternativeName: fullName evidence="1"Flap structure-specific endonuclease 1 |
| geneName | FEN1 At5g26680 F21E10.3 |
| identifier | O65251 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing DNA damage DNA repair DNA replication Endonuclease Exonuclease Hydrolase Magnesium Metal-binding Mitochondrion Nuclease Nucleus Phosphoprotein Reference proteome |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | FEN1 |
| otherIdentifier | O65251_ARATH O65251 246838_at AT5G26680 _ARATH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FEN1_ARATH |
| sequenceLength | 383 |
| species | [Species:170905] Arabidopsis thaliana |
| (isoformParent) | [ReferenceIsoform:8967405] UniProt:O65251-1 FEN1 [Arabidopsis thaliana] |
| (referenceEntity) | [EntityWithAccessionedSequence:1599181] FEN1 [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:O65251 FEN1 (1600940)
