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Details on Person UniProt:Q9FV70 E2FC
| Class:Id | ReferenceGeneProduct:1600928 |
|---|---|
| _chainChangeLog | chain:1-396 added on Fri February 6 2015 |
| _displayName | UniProt:Q9FV70 E2FC |
| _timestamp | 2023-11-03 15:26:50 |
| chain | chain:1-396 |
| checksum | 8D071E79F81BF567 |
| comment | FUNCTION Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex.SUBUNIT Heterodimer with DP proteins. Interacts preferentially with DPB, but also with DPA. No interaction with DPB when phosphorylated. Interacts with SKP2A, CDKA-1 and maize retinoblastoma-related protein RBR1. Component of a DREAM-like complex which modulates a variety of developmentally regulated genes and of the mitotic genes in proliferating and differentiated cells. Interacts with MYB3R3 at later stages of leaves development (PubMed:26069325).INTERACTION Interaction with either DPA or DPB are unable to induce a nuclear localization.ALTERNATIVE PRODUCTS A number of isoforms are produced. According to EST sequences.TISSUE SPECIFICITY Expressed in meristematic areas, vascular tissues, apical part of the roots, cotyledons, upper region of the hypocotyls, trichomes, young flower buds and pollen grains.DEVELOPMENTAL STAGE Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2.INDUCTION Down-regulated by light.DOMAIN The N-terminal region (1-100) is important for both SKP2A binding and ubiquitin-mediated degradation.PTM Phosphorylated by cyclin-dependent kinase. Phosphorylation is necessary to target E2FC for proteolysis.SIMILARITY Belongs to the E2F/DP family. |
| created | [InstanceEdit:1598031] Couchman, M, 2007-06-12 |
| crossReference | [DatabaseIdentifier:1599802] ATIDB:AT1G47870 [DatabaseIdentifier:1599823] TAIR:AT1G47870 [DatabaseIdentifier:1600147] MIPS:AT1G47870 [DatabaseIdentifier:1600148] NCBI Entrez Gene:AT1G47870 [DatabaseIdentifier:1600147] MIPS:AT1G47870 [DatabaseIdentifier:1600148] NCBI Entrez Gene:AT1G47870 [DatabaseIdentifier:1600149] TIGR:AT1G47870 [DatabaseIdentifier:1600149] TIGR:AT1G47870 |
| description | recommendedName: Transcription factor E2FC alternativeName: E2F transcription factor-2 shortName: AtE2F2 |
| geneName | E2FC E2F2 At1g47870 T2E6.2 |
| identifier | Q9FV70 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell cycle Coiled coil Cytoplasm DNA-binding Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | E2FC |
| otherIdentifier | AT1G47870 Q9FV70_ARATH Q9FV70 261741_at |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | E2FC_ARATH Q94LY0 Q9FZG7 |
| sequenceLength | 396 |
| species | [Species:170905] Arabidopsis thaliana |
| (isoformParent) | [ReferenceIsoform:8968267] UniProt:Q9FV70-1 E2FC [Arabidopsis thaliana] |
| (referenceEntity) | [EntityWithAccessionedSequence:1599055] E2Fc-phosphorylated [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599140] E2Fc [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599397] E2Fc [cytosol] [Arabidopsis thaliana] |
| (referenceSequence) | [ModifiedResidue:1600820] phosphate [nucleoplasm] on unknown residue of UNIPROT:Q9FV70_ARATH E2F transcription factor-2 E2F2 |
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No pathways have been reviewed or authored by UniProt:Q9FV70 E2FC (1600928)
