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Details on Person UniProt:Q8GY31 CDC25
| Class:Id | ReferenceGeneProduct:1600902 |
|---|---|
| _chainChangeLog | chain:1-146 added on Sat February 7 2015 |
| _displayName | UniProt:Q8GY31 CDC25 |
| _timestamp | 2025-08-15 21:44:01 |
| chain | chain:1-146 |
| checksum | EA2DD0E79784D538 |
| comment | FUNCTION Tyrosine protein phosphatase that dephosphorylates CDK complex and activate its kinase activity in vitro.FUNCTION Arsenate reductase that plays a major role in the reduction of arsenate to arsenite and arsenic retention in roots (PubMed:16567632). Has an in vitro and in vivo arsenate reductase activity (PubMed:16507083, PubMed:16766666, PubMed:22562211). Plays no role in arsenic metabolism (PubMed:22879969, PubMed:25464340).CATALYTIC ACTIVITY O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphateCATALYTIC ACTIVITY [glutaredoxin]-dithiol + arsenate + glutathione + H(+) = glutathionyl-S-S-[glutaredoxin] + arsenite + H2OACTIVITY REGULATION Inhibited by NSC95397.BIOPHYSICOCHEMICAL PROPERTIES Expressed in roots and at lower levels in shoots (at protein level). Expressed in leaves, stems and flowers.DISRUPTION PHENOTYPE No visible phenotype under normal growth conditions, but plants show reduced root size when grown in presence of hydroxyurea (PubMed:20647223). No visible phenotype, but decreased accumulation of total arsenic in shoots (PubMed:16507083). No effect on arsenate sensitivity (PubMed:25099865). No effect on the accumulation of arsenate in roots, efflux of arsenite or uptake of arsenate, or the total arsenic accumulation in shoots (PubMed:22879969, PubMed:25464340).MISCELLANEOUS Binds 1 zinc ion which is not required for enzyme activity (PubMed:15329414). Plants silencing ACR2 show increased sensitivity to arsenate but not arsenite (PubMed:16567632).SIMILARITY Belongs to the MPI phosphatase family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:1598031] Couchman, M, 2007-06-12 |
| crossReference | [DatabaseIdentifier:1599743] ATIDB:AT5G03455 [DatabaseIdentifier:1599662] TAIR:AT5G03455 [DatabaseIdentifier:1600073] MIPS:AT5G03455 [DatabaseIdentifier:1600074] NCBI Entrez Gene:AT5G03455 [DatabaseIdentifier:1600075] TIGR:AT5G03455 |
| description | recommendedName: fullName evidence="12"Dual specificity phosphatase Cdc25 ecNumber evidence="2"3.1.3.48 alternativeName: fullName evidence="12"Arath;CDC25 alternativeName: fullName evidence="13"Arsenate reductase shortName evidence="13"AtASR alternativeName: fullName evidence="14"Arsenate reductase 2 ecNumber evidence="7"1.20.4.1 alternativeName: fullName evidence="15"Sulfurtransferase 5 shortName evidence="15"AtStr5 |
| geneName | CDC25 ACR2 ASR STR5 At5g03455 F12E4_220 |
| identifier | Q8GY31 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Cell division Hydrolase Metal-binding Mitosis Nucleus Oxidoreductase Protein phosphatase Reference proteome Zinc |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CDC25 |
| otherIdentifier | AT5G03455 CDC25_ARATH CDC25 250923_at Q8GY31 Q8GY31_ARATH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CDC25_ARATH Q8LC90 Q9LZE1 |
| sequenceLength | 146 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599422] CDC25-like protein [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q8GY31 CDC25 (1600902)
