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Details on Person UniProt:Q9M077 AUR1
| Class:Id | ReferenceGeneProduct:1600892 |
|---|---|
| _chainChangeLog | chain:1-294 added on Fri February 6 2015 |
| _displayName | UniProt:Q9M077 AUR1 |
| _timestamp | 2025-05-21 21:47:45 |
| chain | chain:1-294 |
| checksum | B6669E1799083BE4 |
| comment | FUNCTION Phosphorylates specifically 'Ser-10' of histone H3 in vitro and colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Also colocalizes with gamma-tubulin and function in microtubule organizing centers (MTOCs). In contrast with the mammalian B-type Aurora, AUR1 has no kinase activity toward 'Ser-28' of histone H3.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with TPX2.SUBCELLULAR LOCATION Nuclear membrane in interphase cells, spindle poles at prophase, mitotic spindle from metaphase to telophase and equatorial cell plate at telophase.TISSUE SPECIFICITY Abundant in roots, flowers and flower buds, low or absent in expanded leaves, stems and siliques.DEVELOPMENTAL STAGE Peak of expression at mitosis.PTM Phosphorylation at Thr-185 may regulate activity and degradation of AUR1 in a cell cycle dependent manner.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. |
| created | [InstanceEdit:1597970] Couchman, M, 2007-07-03 |
| crossReference | [DatabaseIdentifier:1599736] ATIDB:AT4G32830 [DatabaseIdentifier:1600047] TAIR:AT4G32830 [DatabaseIdentifier:1600048] MIPS:AT4G32830 [DatabaseIdentifier:1600049] NCBI Entrez Gene:AT4G32830 [DatabaseIdentifier:1600050] TIGR:AT4G32830 [DatabaseIdentifier:1600050] TIGR:AT4G32830 |
| description | recommendedName: Serine/threonine-protein kinase Aurora-1 shortName: AtAur1 ecNumber: 2.7.11.1 alternativeName: Aurora-like kinase 1 |
| geneName | AUR1 At4g32830 T16I18.40 |
| identifier | Q9M077 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell cycle Cell division Cytoplasm Cytoskeleton Kinase Membrane Microtubule Mitosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | AUR1 |
| otherIdentifier | AT4G32830 AUR1_ARATH AUR1 253403_at Q9M077 Q9M077_ARATH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AUR1_ARATH Q8LBX4 |
| sequenceLength | 294 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599298] AURORA1 [spindle] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599376] AURORA1 [nuclear envelope] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q9M077 AUR1 (1600892)
