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Details on Person UniProt:Q9LVN7 POLD1
| Class:Id | ReferenceGeneProduct:1600885 |
|---|---|
| _chainChangeLog | chain:1-1095 for 1600885 added on Fri Nov 03 2023 |
| _displayName | UniProt:Q9LVN7 POLD1 |
| _timestamp | 2025-02-21 19:06:02 |
| chain | chain:1-1095 |
| checksum | 08FDA368381198F1 |
| comment | FUNCTION This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.CATALYTIC ACTIVITY DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphateCOFACTOR Binds 1 [4Fe-4S] cluster.SUBUNIT Heterodimer with subunits of 125 kDa and 50 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity (By similarity).SUBCELLULAR LOCATION A number of isoforms are produced. According to EST sequences.DOMAIN The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.MISCELLANEOUS In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.SIMILARITY Belongs to the DNA polymerase type-B family. |
| created | [InstanceEdit:1598120] Couchman, M, 2007-07-02 |
| crossReference | [DatabaseIdentifier:1600031] ATIDB:At5g63960 [DatabaseIdentifier:1600032] TAIR:At5g63960 [DatabaseIdentifier:1600033] MIPS:At5g63960 [DatabaseIdentifier:1600034] NCBI Entrez Gene:At5g63960 [DatabaseIdentifier:1600035] TIGR:At5g63960 |
| description | recommendedName: DNA polymerase delta catalytic subunit ecNumber: 2.7.7.7 alternativeName: Protein EMBRYO DEFECTIVE 2780 |
| geneName | POLD1 EMB2780 At5g63960 MBM17.6 |
| identifier | Q9LVN7 |
| isSequenceChanged | FALSE |
| keyword | 4Fe-4S Alternative splicing DNA replication DNA-binding DNA-directed DNA polymerase Exonuclease Hydrolase Iron Iron-sulfur Metal-binding Nuclease Nucleotidyltransferase Nucleus Reference proteome Transferase Zinc Zinc-finger |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | POLD1 |
| otherIdentifier | DPOD1_ARATH DPOD1 247311_at AT5G63960 Q9LVN7 Q9LVN7_ARATH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DPOD1_ARATH A0MA44 |
| sequenceLength | 1095 |
| species | [Species:170905] Arabidopsis thaliana |
| (isoformParent) | [ReferenceIsoform:8971893] UniProt:Q9LVN7-1 POLD1 [Arabidopsis thaliana] |
| (referenceEntity) | [EntityWithAccessionedSequence:1599216] POLD1 [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q9LVN7 POLD1 (1600885)
