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Details on Person UniProt:Q9C587 RFC1
| Class:Id | ReferenceGeneProduct:1600880 |
|---|---|
| _chainChangeLog | chain:1-956 for 1600880 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q9C587 RFC1 |
| _timestamp | 2024-02-26 04:52:31 |
| chain | chain:1-956 |
| checksum | 955E2C3DB562088B |
| comment | FUNCTION Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation. Is required in meiosis for DNA double-strand break (DSB) repair during meiotic homologous recombination. May participate in the RAD51-mediated recombination intermediate repair process. Is important for lagging strand synthesis. Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates.SUBUNIT Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex with RFC1.SUBCELLULAR LOCATION Localizes to the chromosomes during zygotene and pachytene.TISSUE SPECIFICITY Expressed at high levels in flowers and siliques, and at lower levels in roots, stems and leaves.DISRUPTION PHENOTYPE The rfc1-1 EMS mutants show reduced plant growth and organ size, and early flowering (PubMed:20639449). The rfc1-2 T-DNA mutants have normal vegetative growth, but have greatly reduced fertility due to a meiotic defect and produce short seed pods with very few seeds (PubMed:23144629). The rfc1-3 T-DNA mutant is embryonic lethal when homozygous (PubMed:23144629).SIMILARITY Belongs to the activator 1 large subunit family. |
| created | [InstanceEdit:1598120] Couchman, M, 2007-07-02 |
| crossReference | [DatabaseIdentifier:1600018] ATIDB:At5g22010 [DatabaseIdentifier:1600019] TAIR:At5g22010 [DatabaseIdentifier:1600020] MIPS:At5g22010 [DatabaseIdentifier:1600021] NCBI Entrez Gene:At5g22010 [DatabaseIdentifier:1600022] TIGR:At5g22010 |
| description | recommendedName: Replication factor C subunit 1 shortName: AtRFC1 alternativeName: Activator 1 large subunit alternativeName: Activator 1 subunit 1 |
| geneName | RFC1 At5g22010 T6G21 |
| identifier | Q9C587 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding DNA damage DNA recombination DNA repair DNA replication DNA-binding Meiosis Nucleotide-binding Nucleus Reference proteome |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | RFC1 |
| otherIdentifier | Q9C587_ARATH Q9C587 AT5G22010 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RFC1_ARATH |
| sequenceLength | 956 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599443] RFC1 [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q9C587 RFC1 (1600880)
