Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q9LKZ3 RBR1

Class:Id	ReferenceGeneProduct:1600874
_chainChangeLog	chain:1-1013 added on Fri February 6 2015
_displayName	UniProt:Q9LKZ3 RBR1
_timestamp	2024-08-09 20:01:03
chain	chain:1-1013
checksum	F3CD279ED508C263
comment	FUNCTION Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate (PubMed:18064404, PubMed:21444209). Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation (PubMed:22307083). Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate maintenance during organogenesis and gametogenesis (PubMed:16377572, PubMed:16815954, PubMed:19359496, PubMed:20525851, PubMed:20585548, PubMed:20683442, PubMed:22595674, PubMed:24285791, PubMed:25303364). Required during lateral organ production (PubMed:20525851). Also involved in controlling asymmetric divisions of stem cells in different stem cell niches (PubMed:22921914, PubMed:23104828, PubMed:24302889). Acts as a negative regulator of cell proliferation during leaf and gametophytes development (PubMed:15201912, PubMed:16361519, PubMed:18976913). At later stages of development, restricts the progression through additional endocycles (PubMed:16361519). In the leaf, plays a role in the control of the mesophyll differentiation (PubMed:24118480). Another role is its implication in the regulation of imprinted genes. Acts together with MSI1 to repress the expression of MET1 during gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA (PubMed:18700816). Regulates many genes of the polycomb repressive complex 2 (PRC2) (PubMed:18976913, PubMed:19704913, PubMed:20585548). Plays an important role in meiosis affecting different aspects of this complex process (PubMed:21217641). Functions as a positive regulator of the developmental switch from embryonic heterotrophic growth to autotrophic growth (PubMed:21693514). Interaction with mastrevirus RepA or nanovirus Clink protein disrupts the RBR/E2F interaction and releases the transcription of replicative enzymes needed by the virus by increasing the E2F DNA-binding activity (PubMed:16361519).SUBUNIT Interacts with the begomovirus replication-associated protein (Rep) (PubMed:10880461), the nanovirus Clink protein (PubMed:17267511), the mastrevirus RepA protein, E2FA, E2FB and E2FC (PubMed:16055635, PubMed:16361519, PubMed:18064404, PubMed:20683442, PubMed:22307083). Interacts with MSI1 through its Domain A (PubMed:18700816). Interacts with ATPK1/S6K1 (PubMed:20683442). Interacts with SCR (PubMed:22921914, PubMed:24302889). Interacts with HAT2 (PubMed:24302889). Interacts with FAMA (PubMed:24571519, PubMed:25303364). Interacts with MYB124 and MYB88 (PubMed:24571519). Component of a DREAM-like complex which modulates a variety of developmentally regulated genes and of the mitotic genes in proliferating and differentiated cells. Associates with MYB3R3 in both earlier and later stages of leaves development. Interacts with MYB3R4 only at early stages of leaves development (PubMed:26069325).INTERACTION RBR1 nuclear localization is mediated by the RBR1-ATPK1 interaction.ALTERNATIVE PRODUCTS A number of isoforms are produced. According to EST sequences.TISSUE SPECIFICITY Expressed in actively dividing cells. Detected in the shoot apical meristem, in young leaf primordia and in both sporophytic tissue and the megagametophyte.DEVELOPMENTAL STAGE Highly expressed before and after fertilization (PubMed:15201912). During meiosis, found to localize along the chromosome axes during late G2/early leptotene. As prophase I progressed, a lower expression is detectable at zygotene then more reduced at pachytene. Not detected at later stages (PubMed:21217641).INDUCTION The polycomb repressive complex 2 (PRC2) containing MSI1, MEA, FIS2 and FIE repress the paternal RBR allele during pollen and seed development (PubMed:18976913). Down-regulated by TCP15 (PubMed:21992944).PTM Highly phosphorylated by CDKA-1 during G1 to S phase transition. Once hyper-phosphorylated, becomes inactive and unable to interact with E2F.PTM Ubiquitinated (Probable). Subject to proteasome-dependent degradation during sucrose starvation (PubMed:21444209).DISRUPTION PHENOTYPE Plants are gametophytic lethals (PubMed:15201912). During meiosis, reduction in the formation of meiotic crossing-overs and a failure of chromosome synapsis, leading to a dramatic reduction in fertility (PubMed:21217641).SIMILARITY Belongs to the retinoblastoma protein (RB) family.
created	[InstanceEdit:1598031] Couchman, M, 2007-06-12
crossReference	[DatabaseIdentifier:1599740] ATIDB:At3g12280 [DatabaseIdentifier:1599715] TAIR:At3g12280 [DatabaseIdentifier:1600000] MIPS:At3g12280 [DatabaseIdentifier:1600001] NCBI Entrez Gene:At3g12280 [DatabaseIdentifier:1600000] MIPS:At3g12280 [DatabaseIdentifier:1600001] NCBI Entrez Gene:At3g12280 [DatabaseIdentifier:1600002] TIGR:At3g12280
description	recommendedName: Retinoblastoma-related protein 1 shortName: AtRBR shortName: AtRBR1
geneName	RBR1 RBR At3g12280 F28J15.11
identifier	Q9LKZ3
isSequenceChanged	FALSE
keyword	Alternative splicing Cell cycle DNA-binding Host-virus interaction Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation
modified	[InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09
name	RBR1
otherIdentifier	Q93ZS5_ARATH Q93ZS5 Q9LKZ3_ARATH Q9LKZ3 256268_at Q9C7C9_ARATH Q9C7C9 AT3G12280
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	RBR1_ARATH Q93ZS5 Q9C7C9 Q9LHH8
sequenceLength	1013
species	[Species:170905] Arabidopsis thaliana
(isoformParent)	[ReferenceIsoform:8974448] UniProt:Q9LKZ3-1 RBR1 [Arabidopsis thaliana]
(referenceEntity)	[EntityWithAccessionedSequence:1599178] RbR-phosphorylated [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599310] RbR [nucleoplasm] [Arabidopsis thaliana]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q9LKZ3 RBR1 (1600874)