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Details on Person UniProt:Q94BT6 ADO1

Class:Id	ReferenceGeneProduct:1600861
_chainChangeLog	chain:1-609 added on Fri February 6 2015
_displayName	UniProt:Q94BT6 ADO1
_timestamp	2023-11-03 15:24:37
chain	chain:1-609
checksum	B25192FCBE019093
comment	FUNCTION Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with NFXL2. Interacts (via N-terminus) with GI and (via Kelch repeats) with ADO3. Component of an E3 ubiquitin ligase SCF(ADO1) complex composed of SKP1A/ASK1 (or SKP1B/ASK2), CUL1, RBX1 and ADO1. Also interacts with SKP1D/ASK4, SKP1K/ASK11, CRY1, PHYB, APRR1 and APRR5, and probably with SKP1N/ASK14 and SKP1S/ASK19.INTERACTION Nuclear after 9 hours of illumination (afternoon of long days). Cytoplasmic when plant have been subsequently grown 16 hours in light and 5 hours in dark (early morning of long days).ALTERNATIVE PRODUCTS A number of isoforms are produced. According to EST sequences.TISSUE SPECIFICITY Ubiquitously expressed with higher levels in cotyledons and leaves.DEVELOPMENTAL STAGE Mainly present during the light phase, and degraded in a proteasome-dependent manner in dark (at protein level).INDUCTION Not regulated at the transcript level, but circadian-regulation at the protein level with a peak at the end of the subjective day.PTM May be ubiquitinated. Degraded in a proteasome-dependent manner.PTM FMN binds covalently to cysteine after exposure to blue light and is reversed in the dark.DISRUPTION PHENOTYPE Accumulation of ADO3 protein during the morning period and early flowering time.MISCELLANEOUS 'Zeitlupe' means slow motion in German.MISCELLANEOUS 'Adagio' means slowly in Italian.SIMILARITY Belongs to the ADAGIO family.
created	[InstanceEdit:1598236] Couchman, MS
description	recommendedName: Adagio protein 1 alternativeName: Clock-associated PAS protein ZTL alternativeName: F-box only protein 2b shortName: FBX2b alternativeName: Flavin-binding kelch repeat F-box protein 1-like protein 2 shortName: FKF1-like protein 2 alternativeName: LOV kelch protein 1 alternativeName: Protein ZEITLUPE
geneName	ADO1 FKL2 LKP1 ZTL At5g57360 MSF19.2
identifier	Q94BT6
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Biological rhythms Chromophore Cytoplasm Flavoprotein Flowering FMN Kelch repeat Nucleus Photoreceptor protein Receptor Reference proteome Repeat Sensory transduction Ubl conjugation Ubl conjugation pathway
modified	[InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name	ADO1
otherIdentifier	AT5G57360 Q94BT6 Q94BT6_ARATH
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	ADO1_ARATH Q9LDF6
sequenceLength	609
species	[Species:170905] Arabidopsis thaliana
(isoformParent)	[ReferenceIsoform:8969069] UniProt:Q94BT6-1 ADO1 [Arabidopsis thaliana]
(referenceEntity)	[EntityWithAccessionedSequence:1599052] ZTL [cytosol] [Arabidopsis thaliana]
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No pathways have been reviewed or authored by UniProt:Q94BT6 ADO1 (1600861)