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Details on Person UniProt:Q9SU24 ORC1B
| Class:Id | ReferenceGeneProduct:1600857 |
|---|---|
| _chainChangeLog | chain:1-813 added on Fri February 6 2015 |
| _displayName | UniProt:Q9SU24 ORC1B |
| _timestamp | 2024-08-09 18:45:36 |
| chain | chain:1-813 |
| checksum | 5F732C91B00944A8 |
| comment | FUNCTION Essential protein required for ovules fertilization (PubMed:15634699, PubMed:19171893). Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity). H3K4me3 effector that positively regulates the transcription of a subset of genes (PubMed:19171893).SUBUNIT Component of the origin recognition complex (ORC) composed of at least ORC1 (ORC1A or ORC1B), ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle and development dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts directly with ORC2 and ORC5 (PubMed:15358564, PubMed:16179646). Binds mostly unmodified histone H3, and, with lower efficiency, H3K4me1 H3K4me2 and H3K4me3 (PubMed:19171893, PubMed:26876097).INTERACTION Follow a cell-cycle regulation with a peak at the G1/S-phase (PubMed:16179646). Mostly expressed in flower buds, and, to a lower exent, in roots, leaves and stems (PubMed:15358564, PubMed:16179646).DEVELOPMENTAL STAGE Restricted to proliferating cells. First active during embryogenesis, but inactive in mature embryos. Expressed in shoot and root apical meristems. Later observed in lateral root primordia and meristems. Detected in young flower buds, developing anthers and mature pollen.INDUCTION Regulated by E2F (PubMed:16126853, PubMed:16179646). Accumulates rapidly after cell cycle reactivation by sucrose addition following cell cycle arrest mediated by sucrose deprivation (PubMed:15358564, PubMed:16179646).DISRUPTION PHENOTYPE Lethal (PubMed:19171893). Unfertilized ovules but normal pollen tube attraction (PubMed:15634699).SIMILARITY Belongs to the ORC1 family. |
| created | [InstanceEdit:1598120] Couchman, M, 2007-07-02 |
| crossReference | [DatabaseIdentifier:1599960] ATIDB:At4g12620 [DatabaseIdentifier:1599961] TAIR:At4g12620 [DatabaseIdentifier:1599962] MIPS:At4g12620 [DatabaseIdentifier:1599963] NCBI Entrez Gene:At4g12620 [DatabaseIdentifier:1599964] TIGR:At4g12620 |
| description | recommendedName: fullName evidence="15"Origin of replication complex subunit 1B shortName evidence="15"AtORC1b alternativeName: fullName evidence="15"Origin recognition complex 1b protein alternativeName: fullName evidence="14"Protein UNFERTILIZED EMBRYO SAC 13 |
| geneName | ORC1B UNE13 At4g12620 T1P17.210 |
| identifier | Q9SU24 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator ATP-binding DNA replication DNA-binding Magnesium Metal-binding Nucleotide-binding Nucleus Reference proteome Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | ORC1B |
| otherIdentifier | Q9SU24_ARATH Q9SU24 254824_s_at AT4G12620 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ORC1B_ARATH |
| sequenceLength | 813 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599309] ORC1b [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q9SU24 ORC1B (1600857)
