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Details on Person UniProt:Q9LZ78 SIM
| Class:Id | ReferenceGeneProduct:1600847 |
|---|---|
| _chainChangeLog | chain:1-127 added on Sat February 7 2015 |
| _displayName | UniProt:Q9LZ78 SIM |
| _timestamp | 2023-11-03 16:47:36 |
| chain | chain:1-127 |
| checksum | 3CD095F760CBE781 |
| comment | FUNCTION Cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle (PubMed:10952891, PubMed:11882294, PubMed:17098811, PubMed:17764505, PubMed:19717615, PubMed:20194967). Inhibits the kinase activity of CYCD3-1/CDKA-1, CYCD2-1/CDKA-1 and CYCB1-1/CDKB1-1 complexes in a dose dependent manner (PubMed:26546445). Cooperates with SMR1 and SMR2 to promote endoreplication during leaf development (PubMed:26546445). Required for normal trichome endoreplicating cell cycles (PubMed:10952891, PubMed:11882294, PubMed:17098811, PubMed:17764505, PubMed:19717615, PubMed:20194967). Positive regulator of effector-triggered immunity (ETI) (PubMed:25455564).SUBUNIT Interacts with CDKA-1 (PubMed:17098811, PubMed:26546445). Interacts with CYCD2-1, CYCD3-2 and CYCD4-1 (PubMed:17098811). Interacts with CDKB1-1 (PubMed:20706207, PubMed:26546445). Interacts with CPR5 (PubMed:25455564).SUBCELLULAR LOCATION Expressed in the shoot apical meristem, leaf primordia and the elongation zone of the root.INDUCTION Down-regulated by gibberellin (PubMed:19576768). Up-regulated by zeocin treatment (PubMed:21613568).DISRUPTION PHENOTYPE Multicellular trichomes with nuclei showing reduced levels of endoreduplication.MISCELLANEOUS Plants over-expressing SIM are dwarf with serrated leaves containing enlarged cells with increased levels of nuclear DNA. |
| created | [InstanceEdit:1597970] Couchman, M, 2007-07-03 |
| crossReference | [DatabaseIdentifier:1599679] ATIDB:AT5G04470 [DatabaseIdentifier:1599940] TAIR:AT5G04470 [DatabaseIdentifier:1599941] MIPS:AT5G04470 [DatabaseIdentifier:1599942] NCBI Entrez Gene:AT5G04470 [DatabaseIdentifier:1599943] TIGR:AT5G04470 |
| description | recommendedName: fullName evidence="15 16"Cyclin-dependent protein kinase inhibitor SIM alternativeName: Protein SIAMESE |
| geneName | SIM At5g04470 T32M21.70 |
| identifier | Q9LZ78 |
| isSequenceChanged | FALSE |
| keyword | Cell cycle Nucleus Protein kinase inhibitor Reference proteome |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:2455454] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | SIM |
| otherIdentifier | AT5G04470 Q680L7_ARATH Q680L7 Q9LZ78_ARATH Q9LZ78 250844_at |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SIM_ARATH Q680L7 |
| sequenceLength | 127 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599363] SIAMESE [nucleoplasm] [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by UniProt:Q9LZ78 SIM (1600847)
