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Details on Person UniProt:Q9M4A2 SPO11-1
| Class:Id | ReferenceGeneProduct:1600841 |
|---|---|
| _chainChangeLog | chain:1-362 added on Sat February 7 2015 |
| _displayName | UniProt:Q9M4A2 SPO11-1 |
| _timestamp | 2024-08-09 19:43:55 |
| chain | chain:1-362 |
| checksum | AE82942C4F456770 |
| comment | FUNCTION Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763). Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:19763177, PubMed:26917763). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763).CATALYTIC ACTIVITY ATP-dependent breakage, passage and rejoining of double-stranded DNA.COFACTOR Heterotetramer of 2 SPO11 (SPO11-1 and/or SPO11-2) and 2 MTOPVIB chains (Probable). Interacts with MTOPVIB (PubMed:26917763, PubMed:28855712). May form a heterodimer with SPO11-2. Interacts with PRD1 (PubMed:17762870, PubMed:28855712). Does not interact with TOP6B (PubMed:11410368).INTERACTION A number of isoforms are produced. According to EST sequences.TISSUE SPECIFICITY Expressed in shoots, young seedlings, flowers and reproductive tissues. Not found in roots or rosette leaves.DEVELOPMENTAL STAGE Accumulates in early G2 phase and then disappears over a period of between 1 and 5 hours post-S phase.DISRUPTION PHENOTYPE Plants show a semi-sterile phenotype and a drastic decrease of meiotic recombination, indicating that SPO11-2 and SPO11-3 are not functionally redundant. SPO11-1 and SPO11-2 are both required for double-strand breaks induction. Drastic decrease in chiasma formation at metaphase I associated with an absence of synapsis in prophase, due to the inability to make double-strand breaks (DSB) (PubMed:19763177).SIMILARITY Belongs to the TOP6A family. |
| created | [InstanceEdit:1598157] Couchman, M, 2007-08-14 |
| crossReference | [DatabaseIdentifier:1599925] ATIDB:AT3G13170 [DatabaseIdentifier:1599926] TAIR:AT3G13170 [DatabaseIdentifier:1599927] MIPS:AT3G13170 [DatabaseIdentifier:1599928] TIGR:AT3G13170 |
| description | recommendedName: fullName evidence="13"Meiotic recombination protein SPO11-1 shortName evidence="13"AtSPO11-1 ecNumber evidence="14"5.6.2.2 |
| geneName | SPO11-1 At3g13170 MJG19.19 |
| identifier | Q9M4A2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing DNA-binding Isomerase Magnesium Meiosis Metal-binding Nucleus Reference proteome Topoisomerase |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | SPO11-1 |
| otherIdentifier | AT3G13170 Q9M4A2_ARATH Q9M4A2 257179_at |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPO11_ARATH Q9C5S3 Q9LK56 |
| sequenceLength | 362 |
| species | [Species:170905] Arabidopsis thaliana |
| (isoformParent) | [ReferenceIsoform:8973084] UniProt:Q9M4A2-1 SPO11-1 [Arabidopsis thaliana] |
| (referenceEntity) | [EntityWithAccessionedSequence:1599131] AtSPO11-1 [nucleoplasm] [Arabidopsis thaliana] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9M4A2 SPO11-1 (1600841)
