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Details on Person UniProt:Q9C9M7 CDKD-2
| Class:Id | ReferenceGeneProduct:1600826 |
|---|---|
| _chainChangeLog | chain:1-348 for 1600826 added on Tue May 14 2024 |
| _displayName | UniProt:Q9C9M7 CDKD-2 |
| _timestamp | 2025-02-21 19:26:08 |
| chain | chain:1-348 |
| checksum | A32CA3E98204DDAD |
| comment | FUNCTION Forms a stable complex with cyclin CYCH1-1 that phosphorylates human CDK2 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)ACTIVITY REGULATION Activated by phosphorylation by CDKF-1. Down-regulated by phosphorylation by WEE1.SUBUNIT Interacts with CYCH1-1. Binding to CYCH1-1 activates CDK kinase.SUBCELLULAR LOCATION Expressed in suspension cell culture, but not in plant organs.PTM Phosphorylated by CDKF-1 at Ser-162 and Thr-168. Phosphorylated by WEE1 at Tyr-24. Autophosphorylated.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. |
| created | [InstanceEdit:1597970] Couchman, M, 2007-07-03 |
| crossReference | [DatabaseIdentifier:1599723] ATIDB:AT1G66750 [DatabaseIdentifier:1599888] TAIR:AT1G66750 [DatabaseIdentifier:1599889] MIPS:AT1G66750 [DatabaseIdentifier:1599890] NCBI Entrez Gene:AT1G66750 [DatabaseIdentifier:1599888] TAIR:AT1G66750 [DatabaseIdentifier:1599889] MIPS:AT1G66750 [DatabaseIdentifier:1599890] NCBI Entrez Gene:AT1G66750 [DatabaseIdentifier:1599891] TIGR:AT1G66750 [DatabaseIdentifier:1599891] TIGR:AT1G66750 |
| description | recommendedName: Cyclin-dependent kinase D-2 shortName: CDKD;2 ecNumber: 2.7.11.22 ecNumber: 2.7.11.23 alternativeName: CDK-activating kinase 4-At shortName: CAK4-At |
| geneName | CDKD-2 At1g66750 F4N21.12 |
| identifier | Q9C9M7 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell cycle Cell division Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CDKD-2 |
| otherIdentifier | AT1G66750 Q9C9M7_ARATH Q9C9M7 256372_at |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CDKD2_ARATH |
| sequenceLength | 348 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599168] Phospho-(Ser162, Thr168) CDKD;2 [nucleoplasm] [Arabidopsis thaliana] [EntityWithAccessionedSequence:1599179] CDKD;2 [nucleoplasm] [Arabidopsis thaliana] |
| (referenceSequence) | [ModifiedResidue:1600811] phosphate [nucleoplasm] on ChEBI:32848 serine residue 162 of UNIPROT:Q9C9M7_ARATH Cell division protein kinase, putative [ModifiedResidue:1600815] phosphate [nucleoplasm] on ChEBI:32835 threonine residue 168 of UNIPROT:Q9C9M7_ARATH Cell division protein kinase, putative |
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No pathways have been reviewed or authored by UniProt:Q9C9M7 CDKD-2 (1600826)
