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Details on Person UniProt:Q8L4H0 WEE1
| Class:Id | ReferenceGeneProduct:1600825 |
|---|---|
| _chainChangeLog | chain:1-500 added on Fri February 6 2015 |
| _displayName | UniProt:Q8L4H0 WEE1 |
| _timestamp | 2025-02-21 19:24:15 |
| chain | chain:1-500 |
| checksum | 7E7C32697B9A9E44 |
| comment | FUNCTION Cell cycle regulatory kinase that is not rate-limiting for cycle progression under normal growth conditions. Transcriptionally activated upon DNA stress or damage in an ATR- or ATM-dependent manner. Once activated, inhibits plant growth by arresting dividing cells in the G2 phase before proceeding into mitosis. Down-regulates CDKA-1 and CDKD-2 by tyrosine phosphorylation. May target principally CDKA-1.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Interacts with CDKA-1, but not with CDKB1-1.SUBCELLULAR LOCATION Expressed in shoot apex, vasculatures tissues of roots and leaves, and developing flowers.INDUCTION By replication blocking agents (hydroxyurea and aphidicolin).DISRUPTION PHENOTYPE Plants show no obvious cell division or endoreduplication phenotype when grown under nonstress conditions, but are hypersensitive to agents that impair DNA replication.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. |
| created | [InstanceEdit:1598031] Couchman, M, 2007-06-12 |
| crossReference | [DatabaseIdentifier:1599806] ATIDB:AT1G02970 [DatabaseIdentifier:1599773] TAIR:AT1G02970 [DatabaseIdentifier:1599885] MIPS:AT1G02970 [DatabaseIdentifier:1599886] NCBI Entrez Gene:AT1G02970 [DatabaseIdentifier:1599887] TIGR:AT1G02970 |
| description | recommendedName: Wee1-like protein kinase ecNumber: 2.7.10.2 alternativeName: Wee1-At |
| geneName | WEE1 At1g02970 F22D16.3 |
| identifier | Q8L4H0 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell cycle Cell division Kinase Magnesium Metal-binding Mitosis Nucleotide-binding Nucleus Reference proteome Transferase Tyrosine-protein kinase |
| modified | [InstanceEdit:1598234] Couchman, MS [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | WEE1 |
| otherIdentifier | AT1G02970 Q8L4H0_ARATH Q8L4H0 262106_at Q9SRY9_ARATH Q9SRY9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | WEE1_ARATH Q9SRY9 |
| sequenceLength | 500 |
| species | [Species:170905] Arabidopsis thaliana |
| (referenceEntity) | [EntityWithAccessionedSequence:1599203] WEE1 [nucleoplasm] [Arabidopsis thaliana] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8L4H0 WEE1 (1600825)
