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Details on Person ATM / ATR phosphorylation of H2AX

Class:Id	Reaction:1599011
_displayName	ATM / ATR phosphorylation of H2AX
_doRelease	TRUE
_timestamp	2016-07-15 23:48:54
authored	[InstanceEdit:1598168] Higgins, JA, 2007-10-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1597933] Higgins, JA, 2007-12-18
input	[CandidateSet:1599478] H2AX [nucleoplasm] [Arabidopsis thaliana]
literatureReference	[LiteratureReference:1600802] ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke [LiteratureReference:1600754] Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related
modified	[InstanceEdit:1597905] Higgins, JA, 2009-03-05 [InstanceEdit:1598079] Higgins, JA, 2009-04-09 [InstanceEdit:1601927] Preece, J, 2011-09-12 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04
name	ATM / ATR phosphorylation of H2AX
output	[CandidateSet:1599505] Phospho-H2AX [nucleoplasm] [Arabidopsis thaliana]
regulatedBy	[Requirement:1598330] Requirement by 'ATR' [Requirement:1598348] Requirement by 'ATM [nucleoplasm]'
regulationReference	[RegulationReference:9641955] Requirement by 'ATR' Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related [RegulationReference:9642968] Requirement by 'ATM [nucleoplasm]' Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related
reviewed	[InstanceEdit:1598068] Doonan, JH, 2008-01-10
species	[Species:170905] Arabidopsis thaliana
stableIdentifier	[StableIdentifier:8879358] R-ATH-1599011.1
(hasEvent)	[Pathway:1598669] ATM and ATR DNA damage pathway [Arabidopsis thaliana]
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No pathways have been reviewed or authored by ATM / ATR phosphorylation of H2AX (1599011)