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Details on Person Plants are continuously exposed to putative DNA-damaging con...
| Class:Id | Summation:1598528 |
|---|---|
| _displayName | Plants are continuously exposed to putative DNA-damaging con... |
| _timestamp | 2011-09-12 23:26:25 |
| created | [InstanceEdit:1597913] Higgins, JA, 2007-10-31 |
| modified | [InstanceEdit:1598012] Higgins, JA, 2007-11-01 [InstanceEdit:1598172] Higgins, JA, 2007-11-01 [InstanceEdit:1598115] Higgins, JA, 2007-11-01 [InstanceEdit:1601927] Preece, J, 2011-09-12 |
| text | Plants are continuously exposed to putative DNA-damaging conditions, such as ultra violet (UV-B) light. The ability of an organism to repair DNA damage in a timely fashion is essential for the integrity and maintenance of the genome. Plants have surveillance mechanisms that enable them to arrest their cell cycle on DNA stress. Signal transduction pathways are involved in sensing DNA damage, pausing the cell division cycle to provide time for repair, inducing repair, and finally releasing the cell cycle from arrest. This arrest allows the cells repair machinery time prior to S phase or M phase to mend the damage. Genomewide transcriptome analysis in response to genotoxin treatment has shown the following affects on cell cycle genes: CYCB1;1, CYCA1;2, E2Fa and WEE1 were upregulated, CYCB1;2 and DEL1 were downregulated. Two DNA repair-defective mutants of Arabidopsis (lig4 and ERCC1) were studied for cell-cycle arrest showing that cell-cycle checkpoint responses to induced DNA damage are differentially regulated in the cells of meristematic versus somatic tissues of plants. The molecular basis of DNA repair is not well characterised in plants. DNA repair is best understood in humans. Please refer to the DNA repair module imported from the Human Reactome [stable identifier = REACT_216.1] |
| (summation) | [Pathway:1598667] G2/M DNA integrity checkpoint [Arabidopsis thaliana] |
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No pathways have been reviewed or authored by Plants are continuously exposed to putative DNA-damaging con... (1598528)
